Document Detail


Neonatal lupus erythematosus in an infant with Turner syndrome.
MedLine Citation:
PMID:  8844749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal lupus erythematosus (NLE) is characterized by transient, annular cutaneous lesions, congenital heart block, and a variety of systemic or hematologic abnormalities. We describe a white infant girl with onset of skin lesions on the face and scalp at 4 days of age. At age 4 weeks she had generalized, erythematous, scaly, annular skin lesions that underwent spontaneous regression at age 5 months. Her mother had no cutaneous or other lesions, but complement examinations revealed the presence of anti-Ro(SSA) and anti-La(SSB) antibodies, and absence of anti-Sm and anti-RNP antibodies. Karyotyping revealed Turner syndrome (TS) with 45,XO sex chromosome constitution. Ro(SSA) and La(SSB) antibodies were found, and direct immunofluorescence testing on healthy skin was positive. At age 5 months, follow-up immunologic examination of the infant had normal results but the mother still had anti-Ro(SSA) and anti-La(SSB) antibodies. We believe that this is the first reported case of NLE in association with TS.
Authors:
E Ruas; A Moreno; O Tellechea; G Rocha; A P Baptista
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric dermatology     Volume:  13     ISSN:  0736-8046     ISO Abbreviation:  Pediatr Dermatol     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1996-12-24     Completed Date:  1996-12-24     Revised Date:  2009-03-03    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  298-302     Citation Subset:  IM    
Affiliation:
Dermatology Clinic, Hospitais da Universidade de Coimbra, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Antinuclear / analysis
Autoantigens / analysis
Facial Dermatoses / complications,  pathology
Female
Fluorescent Antibody Technique, Direct
Follow-Up Studies
Heart Block / congenital
Humans
Infant, Newborn
Karyotyping
Lupus Erythematosus, Cutaneous / complications*,  pathology
Remission, Spontaneous
Ribonucleoproteins, Small Nuclear / immunology
Scalp Dermatoses / complications,  pathology
Turner Syndrome / complications*
X Chromosome
snRNP Core Proteins
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Autoantigens; 0/Ribonucleoproteins, Small Nuclear; 0/SS-A antibodies; 0/SS-B antibodies; 0/snRNP Core Proteins

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