| Neonatal lupus erythematosus in an infant with Turner syndrome. | |
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MedLine Citation:
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PMID: 8844749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonatal lupus erythematosus (NLE) is characterized by transient, annular cutaneous lesions, congenital heart block, and a variety of systemic or hematologic abnormalities. We describe a white infant girl with onset of skin lesions on the face and scalp at 4 days of age. At age 4 weeks she had generalized, erythematous, scaly, annular skin lesions that underwent spontaneous regression at age 5 months. Her mother had no cutaneous or other lesions, but complement examinations revealed the presence of anti-Ro(SSA) and anti-La(SSB) antibodies, and absence of anti-Sm and anti-RNP antibodies. Karyotyping revealed Turner syndrome (TS) with 45,XO sex chromosome constitution. Ro(SSA) and La(SSB) antibodies were found, and direct immunofluorescence testing on healthy skin was positive. At age 5 months, follow-up immunologic examination of the infant had normal results but the mother still had anti-Ro(SSA) and anti-La(SSB) antibodies. We believe that this is the first reported case of NLE in association with TS. |
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Authors:
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E Ruas; A Moreno; O Tellechea; G Rocha; A P Baptista |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric dermatology Volume: 13 ISSN: 0736-8046 ISO Abbreviation: Pediatr Dermatol Publication Date: 1996 Jul-Aug |
Date Detail:
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Created Date: 1996-12-24 Completed Date: 1996-12-24 Revised Date: 2009-03-03 |
Medline Journal Info:
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Nlm Unique ID: 8406799 Medline TA: Pediatr Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 298-302 Citation Subset: IM |
Affiliation:
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Dermatology Clinic, Hospitais da Universidade de Coimbra, Portugal. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Antinuclear
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analysis Autoantigens / analysis Facial Dermatoses / complications, pathology Female Fluorescent Antibody Technique, Direct Follow-Up Studies Heart Block / congenital Humans Infant, Newborn Karyotyping Lupus Erythematosus, Cutaneous / complications*, pathology Remission, Spontaneous Ribonucleoproteins, Small Nuclear / immunology Scalp Dermatoses / complications, pathology Turner Syndrome / complications* X Chromosome snRNP Core Proteins |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antinuclear; 0/Autoantigens; 0/Ribonucleoproteins, Small Nuclear; 0/SS-A antibodies; 0/SS-B antibodies; 0/snRNP Core Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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