Document Detail

Neonatal lupus erythematosus complicated by improved congenital complete heart block.
MedLine Citation:
PMID:  23910804     Owner:  NLM     Status:  In-Data-Review    
Complete congenital heart block (CCHB) accompanied with neonatal lupus erythematosus is caused by an immune reaction between maternal anti-Ro/SSA antibodies and the fetal heart and is generally considered an irreversible process. This reaction mostly occurs before 30 weeks' gestation, especially between the 20th and 24th week. Reported here is an atypical case of neonatal lupus erythematosus with CCHB detected after 32 weeks' gestation that showed postnatal improvement in the degree of heart block after preterm delivery and immunoglobulin use. The clinical condition of the infant worsened with an increase in heart rate due to possible cardiomyopathy induced by the immune reaction.
Tetsuya Isayama; Noboru Inamura; Nobuko Shiono; Hiroyuki Kitajima
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  55     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-08-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  521-4     Citation Subset:  IM    
Copyright Information:
© 2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society.
Department of Neonatology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan.
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