Document Detail

Neonatal low-protein diet changes deiodinase activities and pituitary TSH response to TRH in adult rats.
MedLine Citation:
PMID:  18156306     Owner:  NLM     Status:  MEDLINE    
Protein malnutrition during neonatal programs for a lower body weight and hyperthyroidism in the adult offspring were analyzed. Liver deiodinase is increased in such animals, contributing to the high serum triiodothyronine (T3) levels. The level of deiodinase activities in other tissues is unknown. We analyzed the effect of maternal protein restriction during lactation on thyroid, skeletal muscle, and pituitary deiodinase activities in the adult offspring. For pituitary evaluation, we studied the in vitro, thyrotropin-releasing hormone (TRH)-stimulated thyroid-stimulating hormone (TSH) secretion. Lactating Wistar rats and their pups were divided into a control (C) group, fed a normal diet (23% protein), and a protein-restricted (PR) group, fed a diet containing 8% protein. At weaning, pups in both groups were fed a normal diet until 180 days old. The pituitary gland was incubated before and after TRH stimulation, and released TSH was measured by radioimmunoassay. Deiodinase activities (D1 and D2) were determined by release of (125)I from [(125)I]reverse triiodothyronine (rT3). Maternal protein malnutrition during lactation programs the adult offspring for lower muscle D2 (-43%, P<0.05) and higher muscle D1 (+83%, P<0.05) activities without changes in thyroidal deiodinase activities, higher pituitary D2 activity (1.5 times, P<0.05), and lower TSH response to in vitro TRH (-56%, P<0.05). The evaluations showed that the lower in vivo TSH detected in adult PR hyperthyroid offspring, programmed by neonatal undernutrition, may be caused by an increment of pituitary deiodination. As described for liver, higher skeletal muscle D1 activity suggests a hyperthyroid status. Our data broaden the knowledge about the adaptive changes to malnutrition during lactation and reinforce the concept of neonatal programming of the thyroid function.
P C Lisboa; A T S Fagundes; A T A Denolato; E Oliveira; I T Bonomo; S B Alves; F H Curty; M C F Passos; E G Moura
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  233     ISSN:  1535-3702     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2008-03-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-63     Citation Subset:  IM    
Departamento de Ciências Fisiológicas, Instituto de Biologia Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil 20551-030.
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MeSH Terms
Animals, Suckling
Dietary Proteins / administration & dosage
Glucosephosphate Dehydrogenase / metabolism
Iodide Peroxidase / metabolism*
Liver / drug effects,  enzymology*
Maternal Nutritional Physiological Phenomena*
Mitochondria / metabolism
Pituitary Gland / drug effects,  secretion*
Rats, Wistar
Thyrotropin / secretion*
Thyrotropin-Releasing Hormone / pharmacology*
Reg. No./Substance:
0/Dietary Proteins; 24305-27-9/Thyrotropin-Releasing Hormone; 9002-71-5/Thyrotropin; EC Dehydrogenase; EC Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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