Document Detail

Neonatal and long-term outcomes of very low birth weight infants from single and multiple pregnancies.
MedLine Citation:
PMID:  12234744     Owner:  NLM     Status:  MEDLINE    
The revolution in artificial reproductive technologies has resulted in a dramatic rise in the incidence of multiple pregnancies. Many of these infants are born prematurely, often extremely so. Consequently, perinatal morbidity and mortality are highly correlated with plurality. The primary mechanism for this increased risk is prematurity. Studies of the relationship between plurality and outcome are frequently hampered by major differences in case mix between singletons, twins and high multiples. For example, high multiples tend to receive earlier prenatal care, receive more antenatal steroids, are more often delivered by Caesarean section and more often suffer from respiratory distress syndrome. However, recent studies that appropriately account for relevant confounding variables have suggested that very low birth weight infants from high multiple pregnancies are at excess risk for mortality when compared with twins and singletons. This article reviews the current available evidence.
Eric S Shinwell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in neonatology : SN     Volume:  7     ISSN:  1084-2756     ISO Abbreviation:  Semin Neonatol     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-09-17     Completed Date:  2002-12-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9606001     Medline TA:  Semin Neonatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  203-9     Citation Subset:  IM    
Department of Neonatology, Kaplan Medical Center, Rehovot, Hebrew University, Jerusalem, Israel.
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MeSH Terms
Child Development
Infant Mortality
Infant, Newborn
Infant, Newborn, Diseases / epidemiology,  mortality
Infant, Premature*
Infant, Very Low Birth Weight*
Israel / epidemiology
Pregnancy, Multiple*
Risk Factors

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