Document Detail


Neonatal liver disease.
MedLine Citation:
PMID:  16637557     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Establishing a rapid and accurate diagnosis of the cause of neonatal liver disease is an urgent matter. The initial detection of this condition relies on the sensitivity of the primary care provider or pediatrician to the signs and symptoms of jaundice and abnormal stool and urine color. It is critical to evaluate jaundice in any infant older than 2 weeks with measurement of fractionated bilirubin, and further assessment is necessary if the direct value is above 1.0 mg/dL in the setting of a total bilirubin of less than 5.0 mg/dL or a direct bilirubin of more than 20% of total if the total is more than 5.0 mg/dL. A diagnostic algorithm for the evaluation of infants who meet these criteria can guide physicians in selecting appropriate and timely diagnostic testing and referral to pediatric gastroenterology for these patients, whose outcome will rely on rapid diagnosis.
Authors:
Karan McBride Emerick; Peter F Whitington
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pediatric annals     Volume:  35     ISSN:  0090-4481     ISO Abbreviation:  Pediatr Ann     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-26     Completed Date:  2006-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0356657     Medline TA:  Pediatr Ann     Country:  United States    
Other Details:
Languages:  eng     Pagination:  280-6     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, Hepatology, and Nutrition, Children's Memorial Hospital, Northwestern University School of Medicine, Chicago, IL, USA. k-emerick@northwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Biliary Atresia / complications*,  diagnosis,  physiopathology
Bilirubin / blood
Cholestasis / complications*,  diagnosis,  etiology
Humans
Infant, Newborn
Jaundice, Neonatal / diagnosis*,  physiopathology
Liver Diseases / diagnosis,  etiology*,  physiopathology
alpha 1-Antitrypsin Deficiency / complications*
Chemical
Reg. No./Substance:
635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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