Document Detail


Neonatal lithium toxicity as a result of maternal toxicity.
MedLine Citation:
PMID:  9080635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lithium carbonate is used for the treatment of bipolar disorder. Because of its widespread use, many women of childbearing age are taking lithium carbonate, which belongs to the US FDA Category D. Administration during pregnancy can result in fetal toxicity. A 17-y-old female with pre-eclampsia and a history of manic depression gave birth to an infant at 37-w gestational age. Several hours prior to delivery, the mother had a lithium level of 2.6 mEq/L. The infant's initial lithium level after birth was 2.1 mEq/L. A subsequent lithium level on the 3rd d of the child's life was 1.4 mEq/L; the half-life in the infant was > 24 h. During the first 4 d of life, the infant was lethargic and exhibited poor suck-swallow coordination that required supplemental enteral feeding. By the 7th d of life, the infant was alert and tolerating all oral feedings. Lithium carbonate readily crosses the placental barrier and can produce teratogenic effects and toxicity. Neonates exposed in utero should be carefully monitored for symptoms of toxicity. In this case only minor toxic effects occurred.
Authors:
B Flaherty; E P Krenzelok
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Veterinary and human toxicology     Volume:  39     ISSN:  0145-6296     ISO Abbreviation:  Vet Hum Toxicol     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-03     Completed Date:  1997-06-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704194     Medline TA:  Vet Hum Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  92-3     Citation Subset:  IM    
Affiliation:
Pittsburgh Poison Center, Children's Hospital of Pittsburgh, PA 15213, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antidepressive Agents / administration & dosage,  adverse effects*,  therapeutic use
Bipolar Disorder / drug therapy*
Female
Gestational Age
Humans
Infant Behavior / drug effects
Infant, Newborn
Lithium / blood
Lithium Carbonate / administration & dosage,  adverse effects*,  therapeutic use
Placenta / metabolism
Pregnancy
Pregnancy Complications / drug therapy*
Prenatal Exposure Delayed Effects*
Sleep Stages / drug effects
Sucking Behavior / drug effects
Chemical
Reg. No./Substance:
0/Antidepressive Agents; 554-13-2/Lithium Carbonate; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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