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Neonatal lipopolysaccharide treatment has long term effects on monoaminergic and cannabinoid receptors in the rat.
MedLine Citation:
PMID:  23389966     Owner:  NLM     Status:  Publisher    
Brain inflammation in early life has been proposed to play important roles in the development of anxiety and psychosis-related behaviours in adulthood, behaviours that rely on the integrity of dopamine and /or serotonin systems. Moreover recent behavioural and anatomical evidence suggests involvement of CB1 receptors in the control of emotion and mood. In the present study, we determined the effects of neonatal LPS treatment on dopamine, serotonin and cannabinoid receptor binding in adulthood. Rats were treated with the bacterial endotoxin lipopolysaccharide (LPS) on postnatal day (PND) 3 and 5. Dopamine D1, D2, serotonin 5HT1A, 5HT2A and serotonin transporter and cannabinoid CB1 receptor binding across several brain regions were measured autoradiographically in adulthood (PND 85). Neonatal LPS treatment caused a significant increase in dopamine D2 in the nucleus accumbens and olfactory tubercle, a decrease in 5HT1A receptor binding in the hippocampus CA1 and ventromedial hypothalamus. A decrease in CB1 receptor binding after neonatal LPS was observed in the amygdala. Neonatal LPS had no significant impact on dopamine D1, serotonin 5HT2A or serotonin transporter binding in any of the brain regions examined. Our results suggest long lasting, region specific effects and differential impact on dopamine, serotonin and cannabinoid receptor systems following neonatal inflammation, that may form the basis for compromised anxiety and psychosis related behaviours. Synapse, 2013. © 2013 Wiley Periodicals, Inc.
Katerina Zavitsanou; Victoria S Dalton; Adam K Walker; Cynthia S Weickert; Luba Sominsky; Deborah M Hodgson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-7
Journal Detail:
Title:  Synapse (New York, N.Y.)     Volume:  -     ISSN:  1098-2396     ISO Abbreviation:  Synapse     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806914     Medline TA:  Synapse     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia; Schizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, Australia; Schizophrenia Research Institute, Sydney, Australia.
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