Document Detail

Neonatal limb ischemia following maternal indomethacin treatment in twin pregnancies.
MedLine Citation:
PMID:  8904478     Owner:  NLM     Status:  MEDLINE    
The prenatal administration of indomethacin in obstetric management has been implicated as a cause of neonatal cardio-pulmonary, gastrointestinal and renal complications. The present report describes two cases of twin pregnancy resulting in premature delivery at the 33rd and 30th week following prolonged maternal indomethacin treatment for 9 and 4 weeks respectively. Neonatal cardiovascular and renal complications were observed and an unusual severe ischemia of a lower limb occured in each of the first twins following insertion of an umbilical arterial line. It is suggested that prolonged antenatal exposure to the drug may increase the systemic arterial constrictive reactivity in some newborn infants and that special caution should be exercised during arterial catheterization of susceptible cases.
I Arad; B Bar-Oz; Y Amit; Z Ergaz; O Peleg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  23     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1995  
Date Detail:
Created Date:  1997-03-11     Completed Date:  1997-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  487-91     Citation Subset:  IM    
Department of Neonatology, Hadassah University Hospital, Jerusalem, Israel.
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MeSH Terms
Cyclooxygenase Inhibitors / adverse effects*
Indomethacin / adverse effects*
Infant, Newborn
Infant, Premature
Ischemia / chemically induced*
Leg / blood supply*
Maternal-Fetal Exchange / physiology
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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