Document Detail

Neonatal life-threatening arrhythmia responding to lidocaine, a probable LQTS3.
MedLine Citation:
PMID:  17320211     Owner:  NLM     Status:  MEDLINE    
Intrauterine and neonatal manifestations of congenital long QT syndrome (LQTS) are associated with a high cardiac risk. We present a newborn, with antecedents of intrauterine premature ventricular contractions, showing in his surface electrocardiogram (ECG): a QTc of 0.69 ms, 2:1 atrioventricular block, autolimited episodes of ventricular tachycardia and Torsade de Pointes. Intravenous esmolol therapy was started, being only partially effective. Because of the ECG phenotype, a LQTS3 is suspected, and intravenous lidocaine was started, achieving sinus rhythm, a normal QTc and no new episodes of ventricular tachycardia. Lidocaine was substituted for oral mexiletine, and esmolol for propranolol. During the follow-up the patient has remained asymptomatic under therapy with propranolol and mexiletine.
Pedro Betrián Blasco; María Isabel Antúnez Jiménez; Luis Hipólito Falcón González; Pedro Suárez Cabrera
Publication Detail:
Type:  Case Reports; Letter     Date:  2007-02-22
Journal Detail:
Title:  International journal of cardiology     Volume:  117     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-27     Completed Date:  2007-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e61-3     Citation Subset:  IM    
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MeSH Terms
Anti-Arrhythmia Agents / administration & dosage*
Infant, Newborn
Lidocaine / administration & dosage*
Long QT Syndrome / complications*,  drug therapy*
Torsades de Pointes / drug therapy*,  etiology*
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 137-58-6/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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