Document Detail

Neonatal iron nutrition.
MedLine Citation:
PMID:  11988032     Owner:  NLM     Status:  MEDLINE    
Preterm infants are prone to iron deficiency. Their total body iron content at birth is low and gets further depleted by clinical practices such as uncompensated phlebotomy losses and exogenous erythropoietin administration during the neonatal period. Early iron deficiency appears to adversely affect cognitive development in human infants. To maintain iron sufficiency and meet the iron demands of catch-up postnatal growth, iron supplementation is prudent in preterm infants. A dose of 2-4 mg/kg/day is recommended for preterm infants who are fed exclusively human milk. A dose of 6 mg/kg/day or more is needed with the use of exogenous erythropoietin or to correct preexisting iron deficiency. However, due to the poor antioxidant capabilities of preterm infants and the potential role of iron in several oxidant-related perinatal disorders, indiscriminate iron supplementation should be avoided.
R Rao; M K Georgieff
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Seminars in neonatology : SN     Volume:  6     ISSN:  1084-2756     ISO Abbreviation:  Semin Neonatol     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2002-05-03     Completed Date:  2002-08-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9606001     Medline TA:  Semin Neonatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  425-35     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ltd.
Division of Neonatology, Department of Pediatrics and Center for Neurobehavioral Development, University of Minnesota, Minneapolis, MN, USA.
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MeSH Terms
Anemia, Iron-Deficiency / therapy
Breast Feeding
Dietary Supplements
Erythropoietin, Recombinant / pharmacology
Ferritins / blood
Infant Nutritional Physiological Phenomena / physiology*
Infant, Newborn
Infant, Premature / physiology*
Iron Overload / physiopathology
Iron, Dietary / administration & dosage*,  analysis
Milk, Human / chemistry
Nutrition Assessment
Nutritional Requirements
Grant Support
Reg. No./Substance:
0/Erythropoietin, Recombinant; 0/Iron, Dietary; 9007-73-2/Ferritins

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