Document Detail

Neonatal intestinal obstruction simulating meconium ileus in infants with long-segment intestinal aganglionosis: radiographic findings that prompt the need for rectal biopsy.
MedLine Citation:
PMID:  16341713     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The initial clinical presentation and radiographic finding of microcolon in children with long-segment intestinal aganglionosis involving the entire colon, ileum and sometimes the jejunum can mimic meconium ileus. This makes the diagnosis difficult for the radiologist and surgeon. OBJECTIVE: To document and describe the clinical and radiographic findings in children with long-segment intestinal aganglionosis who are initially thought to have meconium ileus. MATERIALS AND METHODS: We reviewed the cases of six neonates with long-segment intestinal aganglionosis presenting as meconium ileus at our institutions between 1978 and 2002. We examined the clinical presentation and the radiographic, surgical, and pathologic findings. In addition, 17 cases from the literature were identified and are included in the discussion. RESULTS: A total of 23 cases were reviewed. Right lower quadrant intraluminal calcifications were noted on abdominal radiographs in all six neonates of our series and were described in 13 of the 17 neonates reported in the literature. Similarly, a microcolon was present in five of the six neonates of our series and in 14 of 16 historical neonates (one not reported). CONCLUSION: In a neonate with small-bowel obstruction and a microcolon, the presence of right lower quadrant intraluminal calcifications should raise the suspicion of long-segment intestinal aganglionosis even if the operative findings are typical of meconium ileus and a biopsy should be performed.
Robert A Cowles; Walter E Berdon; Peter D Holt; Carlo Buonomo; Charles J Stolar
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-12-03
Journal Detail:
Title:  Pediatric radiology     Volume:  36     ISSN:  0301-0449     ISO Abbreviation:  Pediatr Radiol     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-11     Completed Date:  2006-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  133-7     Citation Subset:  IM    
Division of Pediatric Surgery, Morgan Stanley Children's Hospital of New York-Presbyterian, Columbia University College of Physicians and Surgeons, 3959 Broadway, Rm. CHN216B, New York, NY 10032, USA.
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MeSH Terms
Calcinosis / radiography
Colon / abnormalities,  innervation,  radiography
Diagnosis, Differential
Hirschsprung Disease / complications,  radiography*,  surgery
Ileus / diagnosis*
Infant, Newborn
Intestinal Obstruction / etiology,  radiography*,  surgery
Meconium / radiography*
Rectum / innervation,  pathology,  radiography*
Retrospective Studies

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