Document Detail


Neonatal intensive care unit stress is associated with brain development in preterm infants.
MedLine Citation:
PMID:  21976396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Although many perinatal factors have been linked to adverse neurodevelopmental outcomes in very premature infants, much of the variation in outcome remains unexplained. The impact on brain development of 1 potential factor, exposure to stressors in the neonatal intensive care unit, has not yet been studied in a systematic, prospective manner.
METHODS: In this prospective cohort study of infants born at <30 weeks gestation, nurses were trained in recording procedures and cares. These recordings were used to derive Neonatal Infant Stressor Scale scores, which were employed to measure exposure to stressors. Magnetic resonance imaging (brain metrics, diffusion, and functional magnetic resonance imaging) and neurobehavioral examinations at term equivalent postmenstrual age were used to assess cerebral structure and function. Simple and partial correlations corrected for confounders, including immaturity and severity of illness, were used to explore these relations.
RESULTS: Exposure to stressors was highly variable, both between infants and throughout a single infant's hospital course. Exposure to a greater number of stressors was associated with decreased frontal and parietal brain width, altered diffusion measures and functional connectivity in the temporal lobes, and abnormalities in motor behavior on neurobehavioral examination.
INTERPRETATION: Exposure to stressors in the Neonatal Intensive Care Unit is associated with regional alterations in brain structure and function. Further research into interventions that may decrease or mitigate exposure to stressors in the neonatal intensive care unit is warranted.
Authors:
Gillian C Smith; Jordan Gutovich; Christopher Smyser; Roberta Pineda; Carol Newnham; Tiong H Tjoeng; Claudine Vavasseur; Michael Wallendorf; Jeffrey Neil; Terrie Inder
Related Documents :
23470326 - Transgenerational effects of neonatal hypoxia-ischemia in progeny.
23622296 - Sudden infant death syndrome: an update and new perspectives of etiology.
9825016 - Reliability of statistics on violent death and suicide in the former ussr, 1970-1990.
15561336 - Mortality from hypertrophic cardiomyopathy in england and wales: clinical and screening...
8404266 - The development of a linkage between count nouns and object categories: evidence from f...
18216736 - Intrauterine growth and infant temperamental difficulties: the generation r study.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-04
Journal Detail:
Title:  Annals of neurology     Volume:  70     ISSN:  1531-8249     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-26     Completed Date:  2012-01-04     Revised Date:  2014-06-17    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  541-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Neurological Association.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Brain / pathology*
Developmental Disabilities / pathology*,  psychology
Female
Humans
Infant Behavior / psychology*
Infant, Newborn
Infant, Premature / growth & development*,  psychology
Intensive Care Units, Neonatal*
Magnetic Resonance Imaging*
Male
Pregnancy
Prospective Studies
Risk Factors
Grant Support
ID/Acronym/Agency:
HD057512/HD/NICHD NIH HHS; R21 HD057512/HD/NICHD NIH HHS; TL1 RR024995/RR/NCRR NIH HHS; TL1 RR024995/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS
Comments/Corrections
Comment In:
Ann Neurol. 2011 Oct;70(4):523-4   [PMID:  22028216 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Internal supravesical hernia: An unusual cause of small bowel obstruction.
Next Document:  Efficacy and safety of enteric-coated mycophenolate sodium in combination with two glucocorticoid re...