| Neonatal intensive care unit stress is associated with brain development in preterm infants. | |
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MedLine Citation:
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PMID: 21976396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Although many perinatal factors have been linked to adverse neurodevelopmental outcomes in very premature infants, much of the variation in outcome remains unexplained. The impact on brain development of 1 potential factor, exposure to stressors in the neonatal intensive care unit, has not yet been studied in a systematic, prospective manner. METHODS: In this prospective cohort study of infants born at <30 weeks gestation, nurses were trained in recording procedures and cares. These recordings were used to derive Neonatal Infant Stressor Scale scores, which were employed to measure exposure to stressors. Magnetic resonance imaging (brain metrics, diffusion, and functional magnetic resonance imaging) and neurobehavioral examinations at term equivalent postmenstrual age were used to assess cerebral structure and function. Simple and partial correlations corrected for confounders, including immaturity and severity of illness, were used to explore these relations. RESULTS: Exposure to stressors was highly variable, both between infants and throughout a single infant's hospital course. Exposure to a greater number of stressors was associated with decreased frontal and parietal brain width, altered diffusion measures and functional connectivity in the temporal lobes, and abnormalities in motor behavior on neurobehavioral examination. INTERPRETATION: Exposure to stressors in the Neonatal Intensive Care Unit is associated with regional alterations in brain structure and function. Further research into interventions that may decrease or mitigate exposure to stressors in the neonatal intensive care unit is warranted. |
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Authors:
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Gillian C Smith; Jordan Gutovich; Christopher Smyser; Roberta Pineda; Carol Newnham; Tiong H Tjoeng; Claudine Vavasseur; Michael Wallendorf; Jeffrey Neil; Terrie Inder |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-10-04 |
Journal Detail:
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Title: Annals of neurology Volume: 70 ISSN: 1531-8249 ISO Abbreviation: Ann. Neurol. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-26 Completed Date: 2012-01-04 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 541-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Neurological Association. |
Affiliation:
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Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Ave., St Louis, MO 63110, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology* Developmental Disabilities / pathology*, psychology Female Humans Infant Behavior / psychology* Infant, Newborn Infant, Premature / growth & development*, psychology Intensive Care Units, Neonatal* Magnetic Resonance Imaging* Male Pregnancy Prospective Studies Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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HD057512/HD/NICHD NIH HHS; TL1 RR024995/RR/NCRR NIH HHS; TL1 RR024995/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS |
| Comments/Corrections | |
Comment In:
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Ann Neurol. 2011 Oct;70(4):523-4
[PMID:
22028216
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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