Document Detail

Neonatal infection with neurotropic influenza A virus affects working memory and expression of type III Nrg1 in adult mice.
MedLine Citation:
PMID:  19362585     Owner:  NLM     Status:  MEDLINE    
Epidemiological studies suggest that early life infections may contribute to the development of psychiatric disorders characterized by cognitive deficits. Here, we studied the effects of a neonatal influenza A/WSN/33 virus infection on locomotor activity, working memory and emotional behavior in adult mice. In addition to wild type mice, immunodeficient (Tap1(-/-)) mice lacking functional CD8(+) T cells, were included in the study to model the potential influence of a genetic deficit relating to virus clearance. Three to four months after the infection, infected Tap1(-/-) mice, but not wild type mice, exhibited deficits in working memory as well as increased rearing activity and anxiety. In the medial prefrontal cortices of these infected Tap1(-/-) mice reduced levels of type III Nrg1 transcripts were observed supporting a role for neuregulin 1 signaling in neuronal circuits involved in working memory. Virus replication, distribution or clearance did not differ between the two genotypes. The lack of CD8(+) T cells, however, appeared to contribute to a more pronounced glia response in Tap1(-/-) than in wild type mice. Thus, the present study suggest that the risk of developing deficits in cognitive and emotional behavior following a CNS infection during brain development is influenced by genetic variation in genes involved in the immune response.
Linnéa Asp; Simret Beraki; Krister Kristensson; Sven Ove Ogren; Håkan Karlsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-10
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  23     ISSN:  1090-2139     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-14     Completed Date:  2009-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  733-41     Citation Subset:  IM    
Department of Neuroscience, Karolinska Institutet, Retzius väg 8, Stockholm, Sweden.
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MeSH Terms
ATP-Binding Cassette Transporters / genetics
Animals, Newborn*
Anxiety / genetics,  psychology
Brain / pathology,  virology
Inflammation / genetics,  pathology
Influenza A virus*
Maze Learning / physiology
Memory, Short-Term / physiology*
Mice, Inbred C57BL
Mice, Knockout
Motor Activity / physiology
Nerve Tissue Proteins / genetics*
Orthomyxoviridae Infections / genetics*,  metabolism,  psychology*
RNA / biosynthesis,  genetics
Reverse Transcriptase Polymerase Chain Reaction
Reg. No./Substance:
0/ATP-Binding Cassette Transporters; 0/Nerve Tissue Proteins; 0/Nrg1 protein, mouse; 0/Tap1 protein, mouse; 63231-63-0/RNA
Comment In:
Brain Behav Immun. 2009 Aug;23(6):732   [PMID:  19409977 ]

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