Document Detail

Neonatal infection and long-term neurodevelopmental outcome in the preterm infant.
MedLine Citation:
PMID:  16645492     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The relationship between infection, the inflammatory response and adverse neurodevelopmental outcome in preterm infants is slowly being elucidated. The developing brain, particularly the periventricular white matter, is vulnerable to cytotoxic and hypoxic/ischemic injury, which places these infants at increased risk for abnormal cognitive and motor functioning. This review summarizes current data evaluating associations between infection and neurodevelopmental outcome in the preterm infant. RECENT FINDINGS: Preterm infants are at risk for intrauterine and postnatal infections. Recent studies have linked infection/inflammation associated with chorioamnionitis, sepsis and necrotizing enterocolitis with adverse neurodevelopmental outcome and impaired growth in preterm infants. Investigators have also shown associations between infection and brain injury, including severe intraventricular hemorrhage and periventricular leukomalacia. Very-low-birth-weight preterm infants are at substantial risk for neonatal infection, with associated morbidity and mortality. It is postulated that exposure of the preterm brain to inflammatory mediators during infectious episodes contributes to brain injury and poor developmental outcome. SUMMARY: Enhanced understanding of the interaction of infection, inflammation and brain injury will be critical to developing strategies to improve neurodevelopmental outcome in preterm infants.
Ira Adams-Chapman; Barbara J Stoll
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in infectious diseases     Volume:  19     ISSN:  0951-7375     ISO Abbreviation:  Curr. Opin. Infect. Dis.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-04-28     Completed Date:  2006-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809878     Medline TA:  Curr Opin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  290-7     Citation Subset:  IM    
Emory University School of Medicine, Department of Pediatrics, Atlanta, Georgia 30322, USA.
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MeSH Terms
Enterocolitis, Necrotizing / complications
Infant, Newborn
Infant, Premature / growth & development*
Infant, Very Low Birth Weight / growth & development
Infection / complications*,  microbiology,  virology
Meningitis / complications,  microbiology,  virology
Nervous System / growth & development*
Sepsis / complications*,  microbiology,  virology

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