Document Detail

Neonatal immune responses to coagulase-negative staphylococci.
MedLine Citation:
PMID:  17609595     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Coagulase-negative staphylococci have emerged as the most common nosocomial pathogen in neonatal intensive care units worldwide. Our understanding of the interactions between coagulase-negative staphylococci and the immune system is incomplete, especially in the newborn. This review summarizes current knowledge on the human immune response to coagulase-negative staphylococci, with particular emphasis on the neonatal innate immune system. RECENT FINDINGS: There are very limited data on innate immune responses to coagulase-negative staphylococci in neonates. Levels of serum proteins, including transplacental anti-coagulase-negative staphylococci immunoglobulin and complement, correlate with gestational age, and this relative deficiency in preterm infants contributes to their suboptimal opsonization and impaired bacterial killing of coagulase-negative staphylococci. In adults, coagulase-negative staphylococci elicit significant cytokine responses in vitro, which are probably partly mediated by Toll-like receptors, including Toll-like receptor type 2, but these pathways have not been characterized in the high-risk neonatal population. SUMMARY: The susceptibility of human preterm neonates to coagulase-negative staphylococci relates partly to the immaturity of the neonatal immune response. Strategies to reduce the burden of coagulase-negative staphylococci infections require a thorough understanding of host-pathogen interactions, particularly the engagement of coagulase-negative staphylococci by the neonatal innate immune system.
Tobias Strunk; Peter Richmond; Karen Simmer; Andrew Currie; Ofer Levy; David Burgner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in infectious diseases     Volume:  20     ISSN:  0951-7375     ISO Abbreviation:  Curr. Opin. Infect. Dis.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-04     Completed Date:  2007-09-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8809878     Medline TA:  Curr Opin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  370-5     Citation Subset:  IM    
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Antibodies, Bacterial / immunology
Bacteremia / immunology
Coagulase / metabolism
Cytokines / metabolism
Immunity, Innate
Immunity, Maternally-Acquired
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / immunology*,  microbiology,  therapy
Phagocytes / immunology
Risk Factors
Staphylococcal Infections / immunology*,  microbiology,  therapy
Staphylococcus / enzymology,  immunology*,  pathogenicity
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antibodies, Bacterial; 0/Coagulase; 0/Cytokines

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