Document Detail

Neonatal hypothyroxinemia: effects of iodine intake and premature birth.
MedLine Citation:
PMID:  9177368     Owner:  NLM     Status:  MEDLINE    
We have investigated the effects of iodine (I) intake on urinary I excretion in preterm (PT) babies up to 2 months after birth and its effect on serum T4, free T4 (FT4), T3, TSH, and thyroglobulin (Tg) levels compared to those in term (T) newborns. Very premature and very sick infants were in negative I balance for the first weeks after birth. Later, these same infants, as well as the other PT and T newborns, were in positive balance; 75- 80% of the ingested I was not accounted for in the urine. The urinary I levels of PT and T neonates cannot be equated to their I intakes. T4, FT4, and T3 levels in PT and T neonates increased with postmenstrual age, whereas Tg decreased and TSH did not change. Serum FT4, T3, Tg, and TSH levels in PT neonates were affected negatively, independently from age, by a low I intake. PT birth also affected T4, FT4, and Tg negatively, independently from I intake and postmenstrual age, for at least 6-8 weeks after birth. Care should be taken to avoid I deficiency in PT neonates. However, even when I intake is adequate, PT newborns are hypothyroxinemic compared to T babies during an important period of brain development. This suggests the possible convenience of interventions that might mimic the intrauterine hormone environment and accelerate maturation.
S Ares; H F Escobar-Morreale; J Quero; S Durán; M J Presas; R Herruzo; G Morreale de Escobar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  82     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-03     Completed Date:  1997-07-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1704-12     Citation Subset:  AIM; IM    
Unidad de Neonatología, Hospital La Paz, Instituto Nacional de Salud, Madrid, Spain.
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MeSH Terms
Creatinine / urine
Fetal Blood
Infant, Newborn / blood*
Infant, Premature / blood*
Iodine / administration & dosage*,  metabolism,  pharmacology
Thyroid Function Tests
Thyroid Gland / physiology
Thyroxine / blood*
Urine / chemistry
Reg. No./Substance:
60-27-5/Creatinine; 7488-70-2/Thyroxine; 7553-56-2/Iodine
Comment In:
J Clin Endocrinol Metab. 1997 Jun;82(6):1701-3   [PMID:  9177367 ]

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