Document Detail


Neonatal hyperbilirubinemia. Evidence for a role of the erythrocyte enzyme activities involved in the detoxification of oxygen radicals.
MedLine Citation:
PMID:  3389126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Determinations of erythrocyte enzyme scavengers of oxygen radicals (glutathione-peroxidase, superoxide-dismutase and catalase) and determinations of erythrocyte age-dependent glycolytic activities (glucose-6-phosphate-dehydrogenase, pyruvate-kinase and glucose-phosphate-isomerase) were carried out in cord blood and in the blood taken on the 4th day of life in 152 newborn infants with different peak bilirubin levels. The enzyme activities scavenging oxygen radicals, glutathione-peroxidase and superoxide-dismutase were significantly lower in infants with peak bilirubinemia higher than 214 mumol/l, compared to less-jaundiced neonates, both at birth and on the 4th day of life; their values correlated negatively with peak bilirubinemia at birth and on the 4th day of life. Glycolytic age-dependent enzyme activities were significantly higher in more jaundiced newborn infants only on the 4th day of life, when their values correlated positively with peak bilirubinemia. The results of this investigation suggest that a deficiency of factors protecting from oxygen toxicity, may play a role in the development of neonatal hemolysis and jaundice.
Authors:
R Bracci; G Buonocore; B Talluri; S Berni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  77     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-08-11     Completed Date:  1988-08-11     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  349-56     Citation Subset:  IM    
Affiliation:
Division of Neonatology, University of Siena, Italy.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Catalase / blood
Erythrocytes / enzymology*
Female
Fetal Blood / enzymology
Glucose-6-Phosphate Isomerase / blood
Glucosephosphate Dehydrogenase / blood
Glutathione Peroxidase / blood
Glycolysis
Humans
Infant, Newborn
Jaundice, Neonatal / enzymology*
Male
Pyruvate Kinase / blood
Superoxide Dismutase / blood
Chemical
Reg. No./Substance:
EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 2.7.1.40/Pyruvate Kinase; EC 5.3.1.9/Glucose-6-Phosphate Isomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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