| Neonatal hyperbilirubinemia. Evidence for a role of the erythrocyte enzyme activities involved in the detoxification of oxygen radicals. | |
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MedLine Citation:
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PMID: 3389126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Determinations of erythrocyte enzyme scavengers of oxygen radicals (glutathione-peroxidase, superoxide-dismutase and catalase) and determinations of erythrocyte age-dependent glycolytic activities (glucose-6-phosphate-dehydrogenase, pyruvate-kinase and glucose-phosphate-isomerase) were carried out in cord blood and in the blood taken on the 4th day of life in 152 newborn infants with different peak bilirubin levels. The enzyme activities scavenging oxygen radicals, glutathione-peroxidase and superoxide-dismutase were significantly lower in infants with peak bilirubinemia higher than 214 mumol/l, compared to less-jaundiced neonates, both at birth and on the 4th day of life; their values correlated negatively with peak bilirubinemia at birth and on the 4th day of life. Glycolytic age-dependent enzyme activities were significantly higher in more jaundiced newborn infants only on the 4th day of life, when their values correlated positively with peak bilirubinemia. The results of this investigation suggest that a deficiency of factors protecting from oxygen toxicity, may play a role in the development of neonatal hemolysis and jaundice. |
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Authors:
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R Bracci; G Buonocore; B Talluri; S Berni |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta paediatrica Scandinavica Volume: 77 ISSN: 0001-656X ISO Abbreviation: Acta Paediatr Scand Publication Date: 1988 May |
Date Detail:
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Created Date: 1988-08-11 Completed Date: 1988-08-11 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0000211 Medline TA: Acta Paediatr Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 349-56 Citation Subset: IM |
Affiliation:
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Division of Neonatology, University of Siena, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Catalase / blood Erythrocytes / enzymology* Female Fetal Blood / enzymology Glucose-6-Phosphate Isomerase / blood Glucosephosphate Dehydrogenase / blood Glutathione Peroxidase / blood Glycolysis Humans Infant, Newborn Jaundice, Neonatal / enzymology* Male Pyruvate Kinase / blood Superoxide Dismutase / blood |
| Chemical | |
Reg. No./Substance:
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EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase; EC 2.7.1.40/Pyruvate Kinase; EC 5.3.1.9/Glucose-6-Phosphate Isomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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