Document Detail

Neonatal herpes simplex infection: keys to early diagnosis.
MedLine Citation:
PMID:  7576888     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To highlight the clinical features of neonatal herpes simplex (HSV) infection that might facilitate earlier diagnosis. METHODOLOGY: Fifteen year retrospective review of proven neonatal HSV cases from a regional neonatal referral unit. RESULTS: Fifteen cases reviewed: 10 with central nervous system (CNS) disease, three with skin, eyes or mouth (SEM) disease and two with disseminated disease (DIS). A median 4 day delay occurred between symptom onset and hospital admission. All cases presented after maternity hospital discharge, most commonly with feeding problems and lethargy. Six patients presented with skin lesions; parental genital herpes was reported in three (20%) cases. Seven infants died, four without acyclovir treatment and three of 11 treated cases. Three of five CNS disease survivors and all infants with SEM disease were normal at follow up. CONCLUSIONS: Acyclovir improves outcome in neonatal HSV infection. To improve outcome further earlier recognition of the non-specific presenting features of the disease is required.
D E Elder; C Minutillo; P J Pemberton
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  31     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-12-12     Completed Date:  1995-12-12     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  307-11     Citation Subset:  IM    
Neonatal Intensive Care Unit, Princess Margaret Hospital for Children, Perth, Australia.
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MeSH Terms
Acyclovir / therapeutic use
Age of Onset
Antiviral Agents / therapeutic use
Herpes Simplex / blood,  cerebrospinal fluid,  complications,  congenital*,  diagnosis,  drug therapy,  epidemiology
Immunoglobulin M / blood
Infant, Newborn
New Zealand / epidemiology
Retrospective Studies
Survival Rate
Treatment Outcome
Reg. No./Substance:
0/Antiviral Agents; 0/Immunoglobulin M; 59277-89-3/Acyclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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