| Neonatal herpes simplex infection: keys to early diagnosis. | |
MedLine Citation:
|
PMID: 7576888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To highlight the clinical features of neonatal herpes simplex (HSV) infection that might facilitate earlier diagnosis. METHODOLOGY: Fifteen year retrospective review of proven neonatal HSV cases from a regional neonatal referral unit. RESULTS: Fifteen cases reviewed: 10 with central nervous system (CNS) disease, three with skin, eyes or mouth (SEM) disease and two with disseminated disease (DIS). A median 4 day delay occurred between symptom onset and hospital admission. All cases presented after maternity hospital discharge, most commonly with feeding problems and lethargy. Six patients presented with skin lesions; parental genital herpes was reported in three (20%) cases. Seven infants died, four without acyclovir treatment and three of 11 treated cases. Three of five CNS disease survivors and all infants with SEM disease were normal at follow up. CONCLUSIONS: Acyclovir improves outcome in neonatal HSV infection. To improve outcome further earlier recognition of the non-specific presenting features of the disease is required. |
Authors:
|
D E Elder; C Minutillo; P J Pemberton |
Related Documents
:
|
22106728 - Cutaneous mercury granuloma: a case report. 8784718 - Gastric dilatation-volvulus in the dog with histological evidence of preexisting inflam... 1274988 - Multifocal eosinophilic granuloma ("hand-schuller-christian disease"). report illustrat... 2365278 - Pharmacotherapy in moyamoya disease. 6979998 - Haemophilus influenzae meningitis in adults. 18788248 - Civilian gunshot injuries to the oro-facial region in calabar, south-south nigeria, 200... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of paediatrics and child health Volume: 31 ISSN: 1034-4810 ISO Abbreviation: J Paediatr Child Health Publication Date: 1995 Aug |
Date Detail:
|
Created Date: 1995-12-12 Completed Date: 1995-12-12 Revised Date: 2007-09-24 |
Medline Journal Info:
|
Nlm Unique ID: 9005421 Medline TA: J Paediatr Child Health Country: AUSTRALIA |
Other Details:
|
Languages: eng Pagination: 307-11 Citation Subset: IM |
Affiliation:
|
Neonatal Intensive Care Unit, Princess Margaret Hospital for Children, Perth, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acyclovir
/
therapeutic use Age of Onset Antiviral Agents / therapeutic use Female Herpes Simplex / blood, cerebrospinal fluid, complications, congenital*, diagnosis, drug therapy, epidemiology Humans Immunoglobulin M / blood Infant, Newborn Male New Zealand / epidemiology Retrospective Studies Survival Rate Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents; 0/Immunoglobulin M; 59277-89-3/Acyclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Technology seduction: lost opportunities in child health?
Next Document: Risk factors for sensorineural hearing loss in extremely premature infants.