Document Detail

Neonatal hepatitis syndrome.
MedLine Citation:
PMID:  15001124     Owner:  NLM     Status:  MEDLINE    
Conjugated hyperbilirubinaemia in an infant indicates neonatal liver disease. This neonatal hepatitis syndrome has numerous possible causes, classified as infective, anatomic/structural, metabolic, genetic, neoplastic, vascular, toxic, immune and idiopathic. Any infant who is jaundiced at 2-4 weeks old needs to have the serum conjugated bilirubin measured, even if he/she looks otherwise well. If conjugated hyperbilirubinaemia is present, a methodical and comprehensive diagnostic investigation should be performed. Early diagnosis is critical for the best outcome. In particular, palliative surgery for extrahepatic biliary atresia has the best chance of success if performed before the infant is 8 weeks old. Definitive treatments available for many causes of neonatal hepatitis syndrome should be started as soon as possible. Alternatively, liver transplantation may be life saving. Supportive care, especially with attention to nutritional needs, is important for all infants with neonatal hepatitis syndrome.
Eve A Roberts
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in neonatology : SN     Volume:  8     ISSN:  1084-2756     ISO Abbreviation:  Semin Neonatol     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2004-03-05     Completed Date:  2004-03-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9606001     Medline TA:  Semin Neonatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  357-74     Citation Subset:  IM    
Division of Gastroenterology and Nutrition, Room 8267, Black Wing, The Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Genetic Predisposition to Disease
Hepatitis / diagnosis*,  etiology,  genetics,  therapy*
Infant, Newborn
Liver Transplantation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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