| Neonatal hemochromatosis: a case report. | |
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MedLine Citation:
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PMID: 19363327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonatal hemochromatosis is a rare disease of iron metabolism, characterized by the excess accumulation of iron in the tissues. This occurs in utero and can lead to fetal demise or an infant who presents with advanced liver disease in the neonatal period. A case of neonatal hemochromatosis is reported in a 37-week infant who presented at birth with thrombocytopenia, coagulopathy, and abnormal liver imaging studies. The diagnoses of infection and metabolic errors were excluded before the confirmation of neonatal hemochromatosis was made. This diagnosis was confirmed by elevated ferritin levels and extrahepatic siderosis excluding the reticuloendothelial system. Anti-oxidant therapy was initiated with N-acetyl cysteine, selenium, vitamins C and E and intravenous immunoglobulin. The infant demonstrated a positive response and was discharged home with outpatient follow up. The clinical presentation of neonatal hemochromatosis is reviewed as well as diagnosis and treatment strategies. |
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Authors:
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Lauree Pearson; Robin Bissinger; Kelly R Romero |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Advances in neonatal care : official journal of the National Association of Neonatal Nurses Volume: 9 ISSN: 1536-0903 ISO Abbreviation: Adv Neonatal Care Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-13 Completed Date: 2009-05-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125644 Medline TA: Adv Neonatal Care Country: United States |
Other Details:
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Languages: eng Pagination: 72-6 Citation Subset: IM |
Affiliation:
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Perinatal Services and College of Nursing, Medical University of South Carolina, Charleston, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antioxidants / administration & dosage Diagnosis, Differential Female Hemochromatosis / blood, diagnosis*, drug therapy, nursing Humans Immunoglobulins, Intravenous / administration & dosage Infant, Newborn Intensive Care Units, Neonatal Liver Failure, Acute / blood, complications*, diagnosis* Male Pregnancy Pregnancy Complications / blood, diagnosis Treatment Outcome alpha-Fetoproteins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Immunoglobulins, Intravenous; 0/alpha-Fetoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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