Document Detail


Neonatal goiter caused by expectorant usage.
MedLine Citation:
PMID:  11592576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A female newborn was admitted with the symptoms of mild respiratory distress, protruding tongue, hypotonicity, cutis marmorata, sclerema, myxedema, abdominal distension, and feeding problems on the first day of life. She had a huge neck mass, a large anterior and posterior fontanel, and hoarse cry. She had no umbilical hernia or jaundice. A history of maternal potassium iodine (expectorant) usage without doctor's advice was obtained; the mother had not attended a clinic throughout the pregnancy. On ultrasonographic examination, the thyroid right lobe was 53 x 31 mm and the left lobe was 34 x 31 mm. The results of thyroid hormone tests on the first day were as follows: T3 20 ng/dl (normal: 32-216 ng/dl), T4 0.9 microg/dl (11.8-22.6 microg/dl), TSH 120 mIU/l (2.5-13.3 mIU/l). This patient is presented to emphasize the role of hypothyroidism in drug-induced neonatal goiter and to discuss the possibility of a life-threatening effect of congenital goiter, i.e. respiratory tract obstruction.
Authors:
I Bostanci; A Sarioģlu; H Ergin; A Akşit; M Cinbiş; N Akalin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  14     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:    2001 Sep-Oct
Date Detail:
Created Date:  2001-10-10     Completed Date:  2002-02-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  1161-2     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Pamukkale University, Denizli, Turkey. ebb@e-kolay.net
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MeSH Terms
Descriptor/Qualifier:
Expectorants / adverse effects*
Female
Goiter / chemically induced*,  ultrasonography
Humans
Infant, Newborn
Maternal-Fetal Exchange*
Potassium Iodide / adverse effects*
Pregnancy
Thyroid Gland / ultrasonography
Thyroxine / blood
Triiodothyronine / blood
Chemical
Reg. No./Substance:
0/Expectorants; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 7681-11-0/Potassium Iodide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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