Document Detail

Neonatal fat digestion and lingual lipase.
MedLine Citation:
PMID:  3105239     Owner:  NLM     Status:  MEDLINE    
Lingual lipase (LL) activity, pH, and products of fat hydrolysis were determined in gastric aspirates from preterm infants who received formula milk feeds by a nasogastric tube. In 1-hourly (n = 9), 2-hourly (n = 8) and 3-hourly (n = 9) fed infants LL activity increased to reach its maximum value at 60, 90, and 120 min respectively after the feeds, and gastric pH levels fell from about 6.0 to less than 3.5. There was a reduction in triglyceride content to 50% of the initial value, measured immediately after a feed, and the products of hydrolysis were mainly diglycerides and FFA. In a subsequent study 3-hourly fed infants (n = 8) had a tube feed followed by a bottle feed, and then a bottle feed followed by a tube feed on successive days (cross-over). The LL activity observed after a bottle feed (mean maximal value 23.8 mumol FFA/ml/h) was significantly higher than after a tube feed (19.1 mumol FFA/ml/h). It is suggested that substantial triglyceride hydrolysis takes place in the stomach due to lingual lipase, and sucking seems to enhance enzyme production.
L J Smith; S Kaminsky; S W D'Souza
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  75     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-05-21     Completed Date:  1987-05-21     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  913-8     Citation Subset:  IM    
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MeSH Terms
Dietary Fats / metabolism*
Enteral Nutrition
Fatty Acids, Nonesterified / metabolism
Gastric Juice / analysis
Hydrogen-Ion Concentration
Infant Food
Infant, Newborn
Infant, Premature / growth & development,  metabolism*
Lipase / metabolism*
Tongue / enzymology*
Triglycerides / metabolism
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Nonesterified; 0/Triglycerides; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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