Document Detail

Neonatal factors influence adult stroke outcome.
MedLine Citation:
PMID:  16545914     Owner:  NLM     Status:  MEDLINE    
Neonatal environment can have important, life-long influences on stress-reactivity and hypothalamic-pituitary-adrenal (HPA) axis regulation. In rodents, brief mother-infant separations have been shown to improve efficiency of the HPA axis, decrease stress-reactivity, and decrease age-related declines in cognitive function. Here, we provide evidence that there are potential costs associated with improved HPA axis regulation, including increased sensitivity to cerebral inflammation and glucocorticoid-mediated neuronal death following stroke. Specifically, brief mother-infant separation decreases the initial corticosteroid response to experimental stroke in adult mice, but increases post-stroke pro-inflammatory cytokine expression, edema, and infarct volume compared to ischemic controls. Brief maternal separation also compromises functional recovery and long-term survival following stroke. In addition, adrenalectomy reverses the effects of brief maternal separation on stroke outcome when corticosterone is replaced at baseline, but not ischemic, concentrations; thus, neonatally separated mice are more sensitized as adults to the detrimental effects of elevated corticosterone during ischemia. Taken together, these data provide the first direct evidence that neonatal environment can substantially influence adult cerebrovascular health.
Tara K S Craft; Ning Zhang; Erica R Glasper; Patricia D Hurn; A Courtney Devries
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-03-20
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  31     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-08     Completed Date:  2006-07-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  601-13     Citation Subset:  IM    
Department of Psychology, The Ohio State University, 51 Psychology Building, 1835 Neil Avenue, Columbus, OH 43210, USA.
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MeSH Terms
Adrenal Glands / physiopathology
Animals, Newborn / physiology*
Blood Flow Velocity
Cerebral Arteries / surgery
Corticosterone / administration & dosage,  blood
Cytokines / analysis
Hypothalamo-Hypophyseal System / physiopathology
Ischemic Attack, Transient
Maternal Deprivation
Mice, Inbred C57BL
Stroke / pathology,  physiopathology*
Reg. No./Substance:
0/Cytokines; 50-22-6/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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