| Neonatal exposure to single doses of estradiol or testosterone programs ovarian follicular development-modified hypothalamic neurotransmitters and causes polycystic ovary during adulthood in the rat. | |
| | |
MedLine Citation:
|
PMID: 21982285 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the hormones participating in early follicular development and hypothalamic neurotransmitters in rats during adulthood. DESIGN: Experimental basic study. SETTING: University animal laboratory. ANIMAL(S): Twenty-three neonatal rats injected with single subcutaneous injection of estradiol valerate (EV), testosterone propionate (TP), or dihydrotestosterone (DHT) and killed by decapitation at 60 days of age. INTERVENTION(S): Measurements of neurotransmitter in ventromedial hypothalamus-arcuate nucleus (VMH-AN) and ovarian morphometry in the adult rat. MAIN OUTCOME MEASURE(S): Noradrenaline (NA), dopamine (DA), serotonin (5-HT), glutamic acid (Glu), and gamma-aminobutyric acid (GABA) content by high performance liquid chromatography medial basal hypothalamus and ovarian morphology. RESULT(S): EV exposure increased 5-HT, DA, NA, and Glu and decreased GABA levels in the VMH-AN. Exposure to TP increased Glu and decreased 5-HT in the VMH-AN. Neonatal EV and TP decreased the number of primordial follicles but EV increased the atresia of antral follicles and TP decreased it. Neonatal exposure to DHT did not cause morphologic changes in the adult ovary. CONCLUSION(S): Neonatal exposure to EV activated the reproductive hypothalamus and permanently modified ovarian follicular development. TP exposure had some similar effects as EV at the hypothalamus, and it modified ovarian development mimicking the effects of EV. This last effect could be through TP conversion to estradiol because DHT, a nonaromatizable androgen, did not modify follicular development. |
| | |
Authors:
|
Ramón Sotomayor-Zárate; Michelle Tiszavari; Gonzalo Cruz; Hernán E Lara |
Related Documents
:
|
21120275 - Effects of uterine cervix constriction on wistar rats. 23218065 - Effect of previous handling experiences on responses of dairy calves to routine husband... 22077165 - A comparison study between different molecular weight polysaccharides derived from lent... 21602605 - Protective effects of endothelin-a receptor antagonist bq123 against lps-induced oxidat... 17520275 - Antagonism of stromal cell-derived factor-1alpha reduces infarct size and improves vent... 6093165 - Sodium appetite decreased by central angiotensin blockade. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-5 |
Journal Detail:
|
Title: Fertility and sterility Volume: - ISSN: 1556-5653 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Laboratory of Neurobiochemistry, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Independencia, Santiago, Chile; Departmento de Fisiologia, Facultad de Ciencias, Universidad de Valparaíso, Valparaiso, Chile. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of postovulatory oocyte aging on DNA methylation imprinting acquisition in offspring oocytes.
Next Document: Changes in marital congruence and quality of life across the transition to parenthood in couples who...