Document Detail

Neonatal ergot poisoning: a persistent iatrogenic illness.
MedLine Citation:
PMID:  16041632     Owner:  NLM     Status:  MEDLINE    
Ergot toxicity in the newborn usually manifests itself as respiratory depression, cyanosis, oliguria, and seizures. Death is usually caused by respiratory failure. A limited number of neonatal cases have been reported worldwide, and almost all cases involved confusion of maternal methylergonovine with neonatal vitamin K. Previous case reports provided little information regarding the effectiveness and dosing of antidotal therapy, especially sodium nitroprusside. A full-term male infant was inadvertently given methylergonovine instead of naloxone at birth. Several hours later, he required intubation for respiratory failure. Peripheral perfusion, ventilation, and renal function improved rapidly with nitroprusside infusion, and he was extubated on the third hospital day. Even asymptomatic newborns should be transferred to a neonatal intensive care unit for close observation after methylergonovine administration because toxicity can be life threatening. Rapid recognition of the therapeutic error, ventilatory support, and prompt administration of sodium nitroprusside should lead to a good outcome.
Stacey A Bangh; Kirk A Hughes; David J Roberts; Steven M Kovarik
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of perinatology     Volume:  22     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-25     Completed Date:  2005-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  IM    
Hennepin Regional Poison Center, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA.
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MeSH Terms
Diagnosis, Differential
Ergotism / diagnosis*
Iatrogenic Disease
Infant, Newborn
Medication Errors*
Methylergonovine / poisoning
Oxytocics / poisoning
Respiratory Distress Syndrome, Newborn / diagnosis*
Reg. No./Substance:
0/Oxytocics; 113-42-8/Methylergonovine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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