Document Detail

Neonatal encephalopathy: an inadequate term for hypoxic-ischemic encephalopathy.
MedLine Citation:
PMID:  22926849     Owner:  NLM     Status:  MEDLINE    
This Point of View article addresses neonatal encephalopathy (NE) presumably caused by hypoxia-ischemia and the terminology currently in wide use for this disorder. The nonspecific term NE is commonly utilized for those infants with the clinical and imaging characteristics of neonatal hypoxic-ischemic encephalopathy (HIE). Multiple magnetic resonance imaging studies of term infants with the clinical setting of presumed hypoxia-ischemia near the time of delivery have delineated a topography of lesions highly correlated with that defined by human neuropathology and by animal models, including primate models, of hypoxia-ischemia. These imaging findings, coupled with clinical features consistent with perinatal hypoxic-ischemic insult(s), warrant the specific designation of neonatal HIE.
Joseph J Volpe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  72     ISSN:  1531-8249     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-28     Completed Date:  2012-11-01     Revised Date:  2013-02-11    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  156-66     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Neurological Association.
Department of Neurology, Harvard Medical School, Children's Hospital Boston, Boston, MA 02115, USA.
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MeSH Terms
Diagnostic Imaging
Disease Models, Animal
Hypoxia-Ischemia, Brain* / diagnosis,  physiopathology,  therapy
Infant, Newborn
Infant, Newborn, Diseases* / diagnosis,  physiopathology,  therapy
Magnetic Resonance Imaging
Pregnancy Complications / physiopathology
Comment In:
Ann Neurol. 2012 Dec;72(6):984-5   [PMID:  23280849 ]

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