Document Detail

Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study.
MedLine Citation:
PMID:  987769     Owner:  NLM     Status:  MEDLINE    
Twenty-one neonates of over 36 weeks' gestation suffered perinatal asphyxia but not chronic hypoxia. Three clinical stages of postanoxic encephalopathy were distinguished. Stage 1 lasted less than 24 hours and was characterized by hyperalertness, uninhibited Moro and stretch reflexes, sympathetic effects, and a normal electroencephalogram. Stage 2 was marked by obtundation, hypotonia, strong distal flexion, and multifocal seizures. The EEG showed a periodic pattern sometimes preceded by continuous delta activity. Infants in stage 3 were stuporous, flaccid, and brain stem and autonomic functions were suppressed. The EEG was isopotential or had infrequent periodic discharges. Infants who did not enter stage 3 and who had signs of stage 2 for less than five days appeared normal in later infancy. Persistence of stage 2 for more than seven days or failure of the EEG to revert to normal was associated with later neurologic impairment or death.
H B Sarnat; M S Sarnat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  33     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-12-03     Completed Date:  1976-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  696-705     Citation Subset:  AIM; IM    
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MeSH Terms
Brain Diseases / etiology*,  physiopathology
Fetal Distress / complications*
Infant, Newborn
Infant, Newborn, Diseases / etiology*,  physiopathology
Myoclonus / physiopathology
Parasympathetic Nervous System / physiopathology
Seizures / physiopathology
Sympathetic Nervous System / physiopathology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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