Document Detail

Neonatal effects of nifedipine and ritodrine for preterm labor.
MedLine Citation:
PMID:  10725475     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We compared nifedipine and ritodrine for treatment of preterm labor with respect to neonatal outcome. METHODS: We conducted an open randomized multicenter study of neonatal outcome in 185 women who received either oral nifedipine (n = 95) or intravenous (IV) ritodrine (n = 90) for treatment of preterm labor. Secondary outcome measures included neonatal mortality and morbidity, especially neonatal intensive care unit (NICU) admission, respiratory distress syndrome (RDS), and intracranial bleeding. RESULTS: There were no significant differences in umbilical artery pH values and Apgar scores between groups. Nifedipine was associated with lower admission rates to the NICU (49% versus 66%; odds ratio 0. 51, confidence interval 0.28, 0.93) compared with ritodrine, and lower incidences of RDS (21% versus 37%; 0.46, 0.24, 0.89), intracranial bleeding (18% versus 31%; 0.48, 0.24, 0.96), and neonatal jaundice (52% versus 67%; 0.53, 0.29, 0.97). Logistic regression analysis showed that even after correction for gestational age at birth, newborn risk of RDS, intracranial bleeding, or neonatal jaundice was significantly lower in the nifedipine group than the ritodrine group. CONCLUSION: Nifedipine for treatment of preterm labor was associated with a lower incidence of neonatal morbidity than ritodrine. That difference appeared to be partly because of the higher tocolytic efficacy of nifedipine and partly because of an intrinsic beneficial effect of nifedipine, or the lack of harmful effects when compared with ritodrine.
D N Papatsonis; J H Kok; H P van Geijn; O P Bleker; H J Adèr; G A Dekker
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  95     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-27     Completed Date:  2000-04-27     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  477-81     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Free Universal Hospital Amsterdam, Academic Medical Center University of Amsterdam, The Netherlands.
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MeSH Terms
Infant, Newborn
Infant, Newborn, Diseases / epidemiology*,  etiology
Nifedipine / therapeutic use*
Obstetric Labor, Premature / prevention & control*
Ritodrine / therapeutic use*
Tocolytic Agents / therapeutic use*
Reg. No./Substance:
0/Tocolytic Agents; 21829-25-4/Nifedipine; 26652-09-5/Ritodrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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