| Neonatal effects of nifedipine and ritodrine for preterm labor. | |
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MedLine Citation:
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PMID: 10725475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We compared nifedipine and ritodrine for treatment of preterm labor with respect to neonatal outcome. METHODS: We conducted an open randomized multicenter study of neonatal outcome in 185 women who received either oral nifedipine (n = 95) or intravenous (IV) ritodrine (n = 90) for treatment of preterm labor. Secondary outcome measures included neonatal mortality and morbidity, especially neonatal intensive care unit (NICU) admission, respiratory distress syndrome (RDS), and intracranial bleeding. RESULTS: There were no significant differences in umbilical artery pH values and Apgar scores between groups. Nifedipine was associated with lower admission rates to the NICU (49% versus 66%; odds ratio 0. 51, confidence interval 0.28, 0.93) compared with ritodrine, and lower incidences of RDS (21% versus 37%; 0.46, 0.24, 0.89), intracranial bleeding (18% versus 31%; 0.48, 0.24, 0.96), and neonatal jaundice (52% versus 67%; 0.53, 0.29, 0.97). Logistic regression analysis showed that even after correction for gestational age at birth, newborn risk of RDS, intracranial bleeding, or neonatal jaundice was significantly lower in the nifedipine group than the ritodrine group. CONCLUSION: Nifedipine for treatment of preterm labor was associated with a lower incidence of neonatal morbidity than ritodrine. That difference appeared to be partly because of the higher tocolytic efficacy of nifedipine and partly because of an intrinsic beneficial effect of nifedipine, or the lack of harmful effects when compared with ritodrine. |
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Authors:
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D N Papatsonis; J H Kok; H P van Geijn; O P Bleker; H J Adèr; G A Dekker |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 95 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-04-27 Completed Date: 2000-04-27 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 477-81 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Free Universal Hospital Amsterdam, Academic Medical Center University of Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Infant, Newborn Infant, Newborn, Diseases / epidemiology*, etiology Male Nifedipine / therapeutic use* Obstetric Labor, Premature / prevention & control* Pregnancy Ritodrine / therapeutic use* Tocolytic Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Tocolytic Agents; 21829-25-4/Nifedipine; 26652-09-5/Ritodrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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