Document Detail

Neonatal early onset group B streptococcal infection. A nine-year retrospective study in a tertiary care hospital.
MedLine Citation:
PMID:  8950734     Owner:  NLM     Status:  MEDLINE    
Retrospectively, morbidity and mortality of neonatal early onset group B streptococcal (GBS) infection were established. Risk factors and prognostic factors were determined. Between 1985 and 1993, 78 patients with early onset GBS disease were identified. The overall mortality rate was 23%. In 60 of 73 cases (82%) at least one of the investigated risk factors was present. Low birth weight was not an independent risk factor. Outcome of 44 of 60 survivors (73%) at the age of at least one year was obtained. Almost 30% of them had sequelae. The most important were spastic disorders and delayed psychomotor development. In 42% of patients with symptoms of GBS-infection within six hours after birth sequelae occurred. There were no sequelae among patients with symptoms after 6 hours. All 9 severely brain damaged infants showed symptoms shortly after birth. Mortality and adverse outcome rate were higher in infants with low gestational age or low 5 minute Apgar scores. Early treatment resulted in less mortality, but not in less sequelae. GBS-sepsis still causes significant mortality and leaves a substantial number of survivors damaged. Alertness to GBS-infection, even in the absence of risk factors, remains crucial for early treatment and good outcome.
A H Adriaanse; I Lagendijk; H L Muytjens; J G Nijhuis; L A Kollée
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  24     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  1996  
Date Detail:
Created Date:  1997-03-06     Completed Date:  1997-03-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  531-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University Hospital Nijmegen, The Netherlands.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Extraembryonic Membranes
Gestational Age
Infant, Low Birth Weight
Infant, Newborn
Labor, Obstetric
Retrospective Studies
Risk Factors
Streptococcal Infections / complications,  drug therapy,  epidemiology*
Streptococcus agalactiae*
Time Factors
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Lactams

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