| Neonatal diabetes mellitus: a model for personalized medicine. | |
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MedLine Citation:
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PMID: 20434356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonatal diabetes mellitus occurs in approximately 1 out of every 100,000 live births. It can be either permanent or transient, and recent studies indicate that is likely to have an underlying genetic cause, particularly when diagnosed before 6 months of age. Permanent neonatal diabetes is most commonly due to activating mutations in either of the genes encoding the two subunits of the ATP-sensitive potassium channel. In most of these patients, switching from insulin to oral sulfonylurea therapy leads to improved metabolic control, as well as possible amelioration of occasional associated neurodevelopmental disabilities. It remains to be determined what is the most appropriate treatment of other causes. The diagnosis and treatment of neonatal diabetes, therefore, represents a model for personalized medicine. |
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Authors:
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Siri Atma W Greeley; Susan E Tucker; Rochelle N Naylor; Graeme I Bell; Louis H Philipson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-04-29 |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: 21 ISSN: 1879-3061 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-02 Completed Date: 2010-11-30 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 464-72 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pediatrics, Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, University of Chicago Pritzker School of Medicine, 5841 S Maryland Ave, MC 1027, Chicago, IL 60637, USA. sgreeley@peds.bsd.uchicago.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus* / drug therapy, genetics, physiopathology, therapy Gene Therapy Humans Hypoglycemic Agents / therapeutic use Individualized Medicine / methods* Infant, Newborn Insulin / genetics Sulfonylurea Compounds / therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
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5T32-DK06458/DK/NIDDK NIH HHS; P60-DK020595/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 0/Sulfonylurea Compounds; 11061-68-0/Insulin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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