Document Detail


Neonatal cord blood subsets and cytokine response to bacterial antigens.
MedLine Citation:
PMID:  19391080     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared lymphocyte subsets and cytokine responses to bacteria among term, preterm infants, and adults. Lymphocyte subset percentages in cord blood (22 preterm, 27 term neonates) and peripheral blood from 21 adults and cytokine/chemokine interleukin (IL)-6, IL-8, IL-10, IL-12, interferon gamma (IFN gamma) responses to Escherichia coli, group B Streptococcus (GBS), Staphylococcus epidermidis, and Lactobacillus plantarum (Lp299v) were assessed by flow cytometry. Preterm compared with term infants had increased CD8 (+) T cells (p = 0.02) and reduced na??ve CD4 (+) T cells (p < 0.0001). Memory T and natural killer (NK) T cells were reduced (p < 0.001) in neonates; NK and CD56 (+)161 (+) NK cells were increased (p < 0.001). CD56 (+)CD8 (+) NK cells were higher in preterm compared with term infants. Despite individual exceptions, cytokine responses in neonates were weaker than adults except for IL-8 response to E. coli in preterm and IL-12 response to Lp299v in term infants. IL-10 responses were weaker in preterm (p = 0.01) and term (p = 0.005) infants to S. epidermidis and to E. coli (p = 0.03 for both) compared with adults. Differences in regulatory subpopulations of NK and T cells between neonates and adults and term compared with preterm infants were observed. These differences rather than intrinsic functional deficiency may account for neonatal cytokine responses to bacteria.
Authors:
John Denton Peoples; Sandy Cheung; Mirjana Nesin; Hong Lin; A M Francesca Tatad; Danthanh Hoang; Jeffrey M Perlman; Susanna Cunningham-Rundles
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-04-23
Journal Detail:
Title:  American journal of perinatology     Volume:  26     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-16     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  647-57     Citation Subset:  IM    
Copyright Information:
Thieme Medical Publishers.
Affiliation:
Department of Pediatrics, Host Defenses Program, Cornell University Weill Medical College, New York, New York 10021, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, Bacterial / pharmacology*
Cells, Cultured
Chemokines / immunology,  metabolism
Confidence Intervals
Cytokines / immunology,  metabolism*
Female
Fetal Blood / cytology*,  immunology
Humans
Infant, Newborn
Infant, Very Low Birth Weight
Interleukin-10 / immunology,  metabolism
Interleukin-12 / immunology,  metabolism
Killer Cells, Natural / immunology,  metabolism
Leukocytes / immunology,  metabolism
Lymphocyte Activation / immunology*
Male
Probability
Sensitivity and Specificity
T-Lymphocyte Subsets / immunology,  metabolism
Term Birth
Grant Support
ID/Acronym/Agency:
CA 29502/CA/NCI NIH HHS; M01 RR 6020/RR/NCRR NIH HHS; M01RR0004/RR/NCRR NIH HHS; NCI R25 105012//PHS HHS
Chemical
Reg. No./Substance:
0/Antigens, Bacterial; 0/Chemokines; 0/Cytokines; 130068-27-8/Interleukin-10; 187348-17-0/Interleukin-12

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