Document Detail


Neonatal complications following in utero exposure to intravenous ritodrine.
MedLine Citation:
PMID:  3604595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intravenous administration of ritodrine for tocolysis has been associated with maternal cardiovascular and metabolic changes. Studies with other tocolytic agents, such as isoxsuprine, have shown an increased neonatal morbidity among infants born soon after failure of such therapy. We examined the potential side effects of maternal intravenous ritodrine therapy in 58 neonates born within 12 h following discontinuation of maternal medication. 'Low dextrostix' was significantly greater in the ritodrine exposed neonates (p less than 0.05) than in the controls. It occurred within a mean 1.0 +/- 0.5 h following birth. The mean 1 min and 5 min Apgar scores, neonatal pH, bicarbonate levels, hypotension and neonatal mortality were comparable in the ritodrine-exposed and control groups of neonates. The occurrence of any of the neonatal morbidity variables, including 'low dextrostix' was not related either to the total dose of ritodrine used or to the interval between drug discontinuation and delivery. Administration of ritodrine by the standard protocol to stop preterm labor is not associated with any significant increase in neonatal morbidity.
Authors:
N J Kazzi; T L Gross; G M Kazzi; T G Williams
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  66     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1987  
Date Detail:
Created Date:  1987-08-11     Completed Date:  1987-08-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  65-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Infant Mortality
Infant, Newborn
Infant, Premature, Diseases / etiology*
Injections, Intravenous
Maternal-Fetal Exchange
Obstetric Labor, Premature / prevention & control*
Pregnancy
Ritodrine / administration & dosage,  adverse effects*
Grant Support
ID/Acronym/Agency:
1P50 HD 11089/HD/NICHD NIH HHS; MO1-RR00210/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
26652-09-5/Ritodrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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