Document Detail

Neonatal complications after intrauterine exposure to SSRI antidepressants.
MedLine Citation:
PMID:  15233148     Owner:  HSR     Status:  MEDLINE    
(1) Newborns exposed to selective serotonin reuptake inhibitor (SSRI) antidepressants towards the end of pregnancy sometimes show signs of agitation, altered muscle tone, and breathing and suction problems. Similar symptoms can occur after exposure to tricyclic antidepressants. (2) These neonatal symptoms have been noted with all five SSRI antidepressants available in France, namely citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline. (3) An estimated 20% to 30% of newborns exposed to an SSRI towards the end of pregnancy are affected. (4) The symptoms are variously attributed to withdrawal or to the drug itself. (5) In practice, doctors should be aware of this risk when considering antidepressant treatment for women in the third trimester of pregnancy. There is no consensus on the treatment of affected newborns, but close monitoring is mandatory.
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prescrire international     Volume:  13     ISSN:  1167-7422     ISO Abbreviation:  Prescrire Int     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-02     Completed Date:  2004-07-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9439295     Medline TA:  Prescrire Int     Country:  France    
Other Details:
Languages:  eng     Pagination:  103-4     Citation Subset:  T    
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MeSH Terms
Antidepressive Agents / adverse effects*,  therapeutic use
Citalopram / adverse effects,  therapeutic use
Depression / drug therapy
Fluoxetine / adverse effects,  therapeutic use
Fluvoxamine / adverse effects,  therapeutic use
Follow-Up Studies
Infant, Newborn
Neonatal Abstinence Syndrome*
Paroxetine / adverse effects,  therapeutic use
Pregnancy / drug effects
Pregnancy Complications
Pregnancy Trimester, Third
Serotonin Uptake Inhibitors / adverse effects*,  therapeutic use
Sertraline / adverse effects,  therapeutic use
Reg. No./Substance:
0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors; 54739-18-3/Fluvoxamine; 54910-89-3/Fluoxetine; 59729-33-8/Citalopram; 61869-08-7/Paroxetine; 79617-96-2/Sertraline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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