| Neonatal coagulopathy in preterm, small-for-gestational-age infants. | |
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MedLine Citation:
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PMID: 12660434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our aim was to determine if antenatal hypoxia was associated with liver dysfunction and coagulation abnormalities in small-for-gestational-age (SGA) infants. Sixteen SGA infants, median gestational age 30 (range 26-32) weeks, who consecutively had had umbilical artery Doppler studies in the week before delivery, were compared to appropriate-for-gestational-age (AGA) controls, who were each matched to an SGA infant for gestational age. The median international normalised ratio (INR) was significantly higher (1.9 vs. 1.3, p < 0.001) and the neutrophil (p = 0.003) and platelet counts (p < 0.001), alkaline phosphatase (p < 0.001) and albumin (p < 0.02) levels significantly lower in the SGA compared to the AGA group. The umbilical artery pulsatility index (PI) was elevated, indicating antenatal hypoxia, in all but 1 of the SGA infants. Multiple linear regression analysis demonstrated that the INR was significantly related to the umbilical artery PI independent of the other variables (p = 0.0002, R(2) = 0.71). These results suggest that the coagulopathy seen in preterm SGA infants might at least be partially explained by antenatal hypoxia affecting the liver and hence vitamin K-dependent coagulation. |
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Authors:
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Simon Hannam; Christoph Lees; Rebecca J Edwards; Anne Greenough |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biology of the neonate Volume: 83 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 2003 |
Date Detail:
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Created Date: 2003-03-27 Completed Date: 2003-10-29 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: Switzerland |
Other Details:
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Languages: eng Pagination: 177-81 Citation Subset: IM |
Copyright Information:
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Copyright 2003 S. Karger AG, Basel |
Affiliation:
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Children Nationwide Regional Neonatal Intensive Care Unit, King's College Hospital, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Coagulation Disorders
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etiology* Case-Control Studies Fetal Hypoxia / complications, physiopathology Humans Infant Mortality Infant, Newborn Infant, Premature* Infant, Small for Gestational Age* Liver / physiopathology Prognosis Pulsatile Flow Ultrasonography, Doppler Ultrasonography, Prenatal Umbilical Arteries / ultrasonography |
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