Document Detail

Neonatal coagulopathy in preterm, small-for-gestational-age infants.
MedLine Citation:
PMID:  12660434     Owner:  NLM     Status:  MEDLINE    
Our aim was to determine if antenatal hypoxia was associated with liver dysfunction and coagulation abnormalities in small-for-gestational-age (SGA) infants. Sixteen SGA infants, median gestational age 30 (range 26-32) weeks, who consecutively had had umbilical artery Doppler studies in the week before delivery, were compared to appropriate-for-gestational-age (AGA) controls, who were each matched to an SGA infant for gestational age. The median international normalised ratio (INR) was significantly higher (1.9 vs. 1.3, p < 0.001) and the neutrophil (p = 0.003) and platelet counts (p < 0.001), alkaline phosphatase (p < 0.001) and albumin (p < 0.02) levels significantly lower in the SGA compared to the AGA group. The umbilical artery pulsatility index (PI) was elevated, indicating antenatal hypoxia, in all but 1 of the SGA infants. Multiple linear regression analysis demonstrated that the INR was significantly related to the umbilical artery PI independent of the other variables (p = 0.0002, R(2) = 0.71). These results suggest that the coagulopathy seen in preterm SGA infants might at least be partially explained by antenatal hypoxia affecting the liver and hence vitamin K-dependent coagulation.
Simon Hannam; Christoph Lees; Rebecca J Edwards; Anne Greenough
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  83     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2003  
Date Detail:
Created Date:  2003-03-27     Completed Date:  2003-10-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  177-81     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Children Nationwide Regional Neonatal Intensive Care Unit, King's College Hospital, London, UK.
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MeSH Terms
Blood Coagulation Disorders / etiology*
Case-Control Studies
Fetal Hypoxia / complications,  physiopathology
Infant Mortality
Infant, Newborn
Infant, Premature*
Infant, Small for Gestational Age*
Liver / physiopathology
Pulsatile Flow
Ultrasonography, Doppler
Ultrasonography, Prenatal
Umbilical Arteries / ultrasonography

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