| Neonatal chronic lung disease in extremely immature baboons. | |
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MedLine Citation:
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PMID: 10508826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A borderline viability model of bronchopulmonary dysplasia (BPD)/chronic lung disease of infancy (CLD) with pathophysiologic parameters consistent with those in extremely immature humans with BPD/CLD is described. After prenatal steroid treatment of pregnant dams, 12 premature baboons were delivered by cesarean-section at 125 d (term gestation, 185 d), treated with exogenous surfactant, and maintained on appropriate oxygen and positive pressure ventilation for at least 1 to 2 mo. In spite of appropriate oxygenation (median FI(O(2)) at 28 d = 0.32; range, 0.21 to 0.50) and ventilatory strategies to prevent volutrauma, the baboons exhibited pulmonary pathologic lesions known to occur in extremely immature humans of less than 1,000 g: alveolar hypoplasia, variable saccular wall fibrosis, and minimal, if any, airway disease. The CLD baboon lungs showed significantly decreased alveolization and internal surface area measurements when compared with term and term + 2-mo air-breathing controls. A decrease in capillary vasculature was evident by PECAM staining, accompanied by dysmorphic changes. Significant elevations of TNF-alpha, IL-6, IL-8 levels, but not of IL-1beta and IL-10, in tracheal aspirate fluids were present at various times during the period of ventilatory support, supporting a role for mediator-induced autoinflammation. IL-8 levels were elevated in necropsy lavages of animals with significant lung infection. This model demonstrates that impaired alveolization and capillary development occur in immature lungs, even in the absence of marked hyperoxia and high ventilation settings. |
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Authors:
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J J Coalson; V T Winter; T Siler-Khodr; B A Yoder |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 160 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-11-16 Completed Date: 1999-11-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1333-46 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, University of Texas Health Science Center-San Antonio, San Antonio, USA. Coalson@uthscsa.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Bronchopulmonary Dysplasia / pathology*, physiopathology, therapy Cell Count Disease Models, Animal* Gestational Age Humans Immunohistochemistry Infant, Newborn Interleukins / analysis Lung / metabolism, pathology Papio Respiration, Artificial Trachea / metabolism, pathology Tumor Necrosis Factor-alpha / analysis |
| Grant Support | |
ID/Acronym/Agency:
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HL52636/HL/NHLBI NIH HHS; HL52646/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukins; 0/Tumor Necrosis Factor-alpha |
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