Document Detail


Neonatal chronic lung disease in extremely immature baboons.
MedLine Citation:
PMID:  10508826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A borderline viability model of bronchopulmonary dysplasia (BPD)/chronic lung disease of infancy (CLD) with pathophysiologic parameters consistent with those in extremely immature humans with BPD/CLD is described. After prenatal steroid treatment of pregnant dams, 12 premature baboons were delivered by cesarean-section at 125 d (term gestation, 185 d), treated with exogenous surfactant, and maintained on appropriate oxygen and positive pressure ventilation for at least 1 to 2 mo. In spite of appropriate oxygenation (median FI(O(2)) at 28 d = 0.32; range, 0.21 to 0.50) and ventilatory strategies to prevent volutrauma, the baboons exhibited pulmonary pathologic lesions known to occur in extremely immature humans of less than 1,000 g: alveolar hypoplasia, variable saccular wall fibrosis, and minimal, if any, airway disease. The CLD baboon lungs showed significantly decreased alveolization and internal surface area measurements when compared with term and term + 2-mo air-breathing controls. A decrease in capillary vasculature was evident by PECAM staining, accompanied by dysmorphic changes. Significant elevations of TNF-alpha, IL-6, IL-8 levels, but not of IL-1beta and IL-10, in tracheal aspirate fluids were present at various times during the period of ventilatory support, supporting a role for mediator-induced autoinflammation. IL-8 levels were elevated in necropsy lavages of animals with significant lung infection. This model demonstrates that impaired alveolization and capillary development occur in immature lungs, even in the absence of marked hyperoxia and high ventilation settings.
Authors:
J J Coalson; V T Winter; T Siler-Khodr; B A Yoder
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  160     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-16     Completed Date:  1999-11-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1333-46     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, University of Texas Health Science Center-San Antonio, San Antonio, USA. Coalson@uthscsa.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Bronchopulmonary Dysplasia / pathology*,  physiopathology,  therapy
Cell Count
Disease Models, Animal*
Gestational Age
Humans
Immunohistochemistry
Infant, Newborn
Interleukins / analysis
Lung / metabolism,  pathology
Papio
Respiration, Artificial
Trachea / metabolism,  pathology
Tumor Necrosis Factor-alpha / analysis
Grant Support
ID/Acronym/Agency:
HL52636/HL/NHLBI NIH HHS; HL52646/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Interleukins; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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