Document Detail

Neonatal cholinergic lesion alters the acoustic structure of infant rat vocalization but not the early cognitive development.
MedLine Citation:
PMID:  22488119     Owner:  NLM     Status:  Publisher    
Cholinergic innervation is critically required for cytoarchitectonic maturation of the cerebral cortex as well as functional assembling of neuronal networks and their behavioral readout. Selective lesion of cortically projecting cholinergic neurons initiated immediately after birth by the immunotoxin 192 IgG-saporin (SAP) led to abnormal wiring of prefrontal-hippocampal networks, yet the neurobehavioral and cognitive consequences of this impairment are still poorly understood. Here, we show that partial cholinergic depletion initiated at birth did not impact the general development of rat pups during the first 2 postnatal weeks, their homing behavior, and the maturation of recognition memory. However, the acoustic structure of infant ultrasonic vocalization was significantly affected by SAP, indicating that early neurobehavioral development relies on intact cholinergic drive. This altered vocalization did not elicit differential maternal care, suggesting that the previously reported SAP-induced behavioral deficits at adulthood are the direct result of cholinergic depletion rather than of abnormal mother-pup interactions. © 2012 Wiley Periodicals, Inc. Dev Psychobiol.
Hanna-Sophie Krüger; Ileana L Hanganu-Opatz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-4
Journal Detail:
Title:  Developmental psychobiology     Volume:  -     ISSN:  1098-2302     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Developmental Neurophysiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Falkenried 94 20251 Hamburg, Germany.
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