Document Detail


Neonatal cholinergic lesion alters the acoustic structure of infant rat vocalization but not the early cognitive development.
MedLine Citation:
PMID:  22488119     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cholinergic innervation is critically required for cytoarchitectonic maturation of the cerebral cortex as well as functional assembling of neuronal networks and their behavioral readout. Selective lesion of cortically projecting cholinergic neurons initiated immediately after birth by the immunotoxin 192 IgG-saporin (SAP) led to abnormal wiring of prefrontal-hippocampal networks, yet the neurobehavioral and cognitive consequences of this impairment are still poorly understood. Here, we show that partial cholinergic depletion initiated at birth did not impact the general development of rat pups during the first 2 postnatal weeks, their homing behavior, and the maturation of recognition memory. However, the acoustic structure of infant ultrasonic vocalization was significantly affected by SAP, indicating that early neurobehavioral development relies on intact cholinergic drive. This altered vocalization did not elicit differential maternal care, suggesting that the previously reported SAP-induced behavioral deficits at adulthood are the direct result of cholinergic depletion rather than of abnormal mother-pup interactions. © 2012 Wiley Periodicals, Inc. Dev Psychobiol.
Authors:
Hanna-Sophie Krüger; Ileana L Hanganu-Opatz
Related Documents :
16480529 - Malnutrition and high childhood mortality among the onge tribe of the andaman and nicob...
8671559 - The association between maternal education and postneonatal mortality. trends in norway...
10405019 - The historical roots of high rates of infant death in aboriginal communities in canada ...
21645789 - Nonclinical factors affecting women's access to trial of labor after cesarean delivery.
2709479 - Continuous monitoring of child mortality from clinic records.
7095219 - Intermediate variables and educational differentials in fertility in korea and the phil...
16510619 - Volume and frequency of breastfeedings and fat content of breast milk throughout the day.
17566429 - Lefties are still a little shorter.
21501429 - Neonatal resuscitation and immediate newborn assessment and stimulation for the prevent...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-4
Journal Detail:
Title:  Developmental psychobiology     Volume:  -     ISSN:  1098-2302     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Developmental Neurophysiology, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Falkenried 94 20251 Hamburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Osseointegration Technique in Patients with Acquired Auricular Deformities and Failed Previous Recon...
Next Document:  Absorption and bioavailability of glucosamine in the rat.