Document Detail


Neonatal chlordecone exposure impairs early learning and retention of active avoidance in the rat.
MedLine Citation:
PMID:  6201755     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of neonatal exposure of rats to chlordecone on the acquisition and retention of active avoidance was investigated. Pups were trained and tested on one-way (preweaning) and/or two-way (post-weaning) active avoidance tasks. Offspring of Fischer-344 rats were administered 1 mg/pup of chlordecone (SC) dissolved in DMSO on postnatal day 4. Body weights were slightly, but significantly, depressed for chlordecone-exposed males (10-11%) and females (7-8%) during preweaning development. Post-weaning body weights were also slightly depressed by the chlordecone treatment (8% for the males, 7% for the females). For pups trained (day 18) on one-way (small to large compartment) active avoidance (OWA), chlordecone treatment increased the number of trials needed to attain the acquisition criterion; the effect was most pronounced in the males. A 72-hr retention test revealed a sex-dependent effect of chlordecone on response latency during the initial test trials. Acquisition of two-way avoidance (TWA) (days 28-30) was superior in female pups relative to males; chlordecone treatment significantly reduced this sex difference in pups which had prior or no prior OWA training. Perhaps most importantly, however, following prior OWA training, vehicle control pups demonstrated a directional bias to make an avoidance response from a small to a large compartment, whereas chlordecone-treated pups executed their avoidance responses in both directions at comparable rates. Similar evidence indicative of a selective retention deficit also characterized TWA performance when a "reversal" procedure was used. A final retention (extinction) session indicated that the chlordecone-treated pups made fewer responses than vehicle-treated controls during the test trials.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
C F Mactutus; H A Tilson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurobehavioral toxicology and teratology     Volume:  6     ISSN:  0275-1380     ISO Abbreviation:  Neurobehav Toxicol Teratol     Publication Date:    1984 Jan-Feb
Date Detail:
Created Date:  1984-06-12     Completed Date:  1984-06-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8104162     Medline TA:  Neurobehav Toxicol Teratol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Avoidance Learning / drug effects*
Body Weight / drug effects
Chlordecone / toxicity*
Corticosterone / blood
Female
Growth / drug effects
Insecticides / toxicity*
Learning / drug effects*
Male
Memory / drug effects*
Rats
Rats, Inbred F344
Retention (Psychology) / drug effects*
Sex Factors
Chemical
Reg. No./Substance:
0/Insecticides; 143-50-0/Chlordecone; 50-22-6/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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