Document Detail


Neonatal chemokine levels and risk of autism spectrum disorders: Findings from a Danish historic birth cohort follow-up study.
MedLine Citation:
PMID:  23267761     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A potential role of chemokines in the pathophysiology of Autism Spectrum Disorders (ASDs) has been previously suggested. In a recent study we examined levels of three inflammatory chemokines (MCP-1, MIP-1α and RANTES) in samples of amniotic fluid of children diagnosed later in life with ASD and controls frequency-matched to cases on gender and year of birth. In this follow-up study, levels of the same chemokines were analyzed postnatally in dried blood spot samples from the same subjects utilizing the Danish Newborn Screening Biobank. Crude estimates showed decreased levels of RANTES. In the adjusted estimates, no differences were found in levels of the three examined chemokines in ASD cases compared to controls. Our findings may cautiously suggest an altered cell-mediated immunity during the early neonatal period in ASD. Further research is needed to examine the relationship between maternal/fetal and neonatal chemokine levels and their role in ASD.
Authors:
Morsi W Abdallah; Nanna Larsen; Jakob Grove; Eva C Bonefeld-Jørgensen; Bent Nørgaard-Pedersen; David M Hougaard; Erik L Mortensen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-22
Journal Detail:
Title:  Cytokine     Volume:  -     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Affiliation:
Section for Epidemiology, Aarhus University HEALTH, Bartholins Allé 2, Aarhus C 8000, Denmark; Department of Clinical Biochemistry and Immunology Statens Serum Institute, Ørestads Boulevard 5, Copenhagen S 2300, Denmark; Department of Psychiatry and Psychotherapy, Rostock University Hospital, University of Rostock, Gehlsheimer Straße 20, Rostock 18147, Germany. Electronic address: morsi.abdallah@med.uni-rostock.de.
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