Document Detail

Neonatal changes in fatty acid profile of phospholipids in rat heart muscle.
MedLine Citation:
PMID:  6860703     Owner:  NLM     Status:  MEDLINE    
The fatty acid composition of rat heart phospholipids was examined during the neonatal and postnatal period. The rats were killed on days 1, 7, 14 and 21 after birth and at the ages of 2 and 6 months. The fatty acyl chain composition of the two major phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE) changed significantly during the first 2 months. In PC there was a marked and immediate increase in stearic acid, a significant but transient increase in arachidonic acid and late increase in linoleic acid content. In PE there was an immediate increase in stearic acid and docosahexaenoic acid, followed by a late increase in linoleic acid content. The observed alterations in fatty acid composition of heart muscle phospholipids resemble changes induced by repeated administration of norepinephrine and subsequent recovery. Neonatal stress and increased cardiac function play an important role in the modification of the fatty acid composition of rat heart muscle phospholipids during early development.
A Gudmundsdottir; S Gudbjarnason
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  752     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  284-90     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / metabolism*
Chemical Phenomena
Fatty Acids / metabolism*
Myocardium / metabolism*
Phosphatidylcholines / metabolism*
Phosphatidylethanolamines / metabolism*
Rats, Inbred Strains
Reg. No./Substance:
0/Fatty Acids; 0/Phosphatidylcholines; 0/Phosphatidylethanolamines

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