| Neonatal bilirubin production-conjugation imbalance: effect of glucose-6-phosphate dehydrogenase deficiency and borderline prematurity. | |
| | |
MedLine Citation:
|
PMID: 15724035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To evaluate relations between production and conjugation of bilirubin in the pathophysiology of jaundice in glucose-6-phosophate dehydrogenase (G6PD) deficient neonates. METHODS: Term and borderline premature (35-37 weeks gestational age), healthy, male, G6PD deficient neonates were studied close to the beginning of the 3rd day. Blood carboxyhaemogobin corrected for inspired CO (COHbc; an index of bilirubin production) and serum total conjugated bilirubin (TCB; a reflection of bilirubin conjugation) were measured in simultaneously drawn blood samples by gas chromatography and reverse phase high performance liquid chromatography respectively. A bilirubin production-conjugation index comprising COHbc/TCB was determined; a high index reflects imbalance between the bilirubin production and conjugation processes. COHbc and TCB individually and the production-conjugation index were studied in relation to serum total bilirubin (STB) concentration. RESULTS: Fifty one G6PD deficient neonates were sampled at 51 (8) hours. COHbc values did not correlate with STB (r=0.22, p=0.15). TCB did correlate inversely with STB (r=-0.42, p=0.004), and there was a positive correlation between the production-conjugation index and STB (r=0.45, p=0.002). The production-conjugation index (median (interquartile range)) was higher in the premature (n=8) than term neonates (2.31 (2.12-3.08) v 1.05 (0.53-1.81), p=0.003). This difference was the result of changes in TCB. CONCLUSIONS: The data show that jaundice in G6PD deficient neonates is the result of an imbalance between production and conjugation of bilirubin with a tendency for inefficient bilirubin conjugation over increased haemolysis in its pathogenesis. Borderline premature infants are at special risk of bilirubin production-conjugation imbalance. |
| | |
Authors:
|
M Kaplan; M Muraca; H J Vreman; C Hammerman; M T Vilei; F F Rubaltelli; D K Stevenson |
Related Documents
:
|
15973025 - Neonatal surgical jaundice revisited. 19443565 - Hyperbilirubinemia and transcutaneous bilirubinometry. 8279225 - Light deprivation increases plasma levels of melatonin during the first 72 h of life in... 7110785 - Effects of theophylline on the neonatal immune response. 1606115 - Prenatal microbiological risk factors associated with preterm birth. 17214185 - Maternal mortality in mafraq district in jordan. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 90 ISSN: 1359-2998 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 2005 Mar |
Date Detail:
|
Created Date: 2005-02-22 Completed Date: 2005-03-22 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: England |
Other Details:
|
Languages: eng Pagination: F123-7 Citation Subset: AIM; IM |
Affiliation:
|
Department of Neonatology, Shaare Zedek Medical Center, PO Box 3235, Jerusalem 91031, Israel. kaplan@cc.huji.ac.il |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bilirubin
/
biosynthesis,
blood,
metabolism* Carboxyhemoglobin / analysis Glucosephosphate Dehydrogenase Deficiency / complications, metabolism* Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases / etiology, metabolism Jaundice, Neonatal / etiology*, metabolism Male Regression Analysis |
| Grant Support | |
ID/Acronym/Agency:
|
RR00070/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
635-65-4/Bilirubin; 9061-29-4/Carboxyhemoglobin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vitamin C supplementation in very preterm infants: a randomised controlled trial.
Next Document: Changes in mortality and morbidities among infants born at less than 25 weeks during the post-surfac...