Document Detail


Neonatal bilirubin production after preterm labor tocolysis with nifedipine.
MedLine Citation:
PMID:  2721333     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the in vivo total bilirubin production, as indexed by the carboxyhemoglobin level (HbCO), of infants whose mothers had ritodrine (RIT) tocolysis or underwent tocolysis with the calcium channel blocker, nifedipine (NIF). No difference in HbCO between the infant groups was detected: NIF 0.67 +/- 0.31% saturation and RIT 0.88 +/- 0.47% saturation. We conclude that NIF is unlikely to cause a clinically important increase in total bilirubin production when used at doses sufficient for tocolysis.
Authors:
J E Ferguson; T E Schutz; D K Stevenson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  12     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1989  
Date Detail:
Created Date:  1989-07-05     Completed Date:  1989-07-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Affiliation:
Department of Gynecology and Obstetrics, Stanford University School of Medicine, Calif.
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / biosynthesis*
Blood Glucose / metabolism
Carboxyhemoglobin / metabolism
Female
Gestational Age
Humans
Infant, Newborn
Nifedipine / adverse effects*
Obstetric Labor, Premature / prevention & control*
Pregnancy
Tocolytic Agents / adverse effects*
Grant Support
ID/Acronym/Agency:
HD-14426/HD/NICHD NIH HHS; RR-00081/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Tocolytic Agents; 21829-25-4/Nifedipine; 635-65-4/Bilirubin; 9061-29-4/Carboxyhemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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