Document Detail


Neonatal autoimmune hypothyroidism: a patient report.
MedLine Citation:
PMID:  21175097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Acquired primary hypothyroidism in neonates and infants under 3 years of age is very rare. Herein we report the case of an infant female affected by acquired autoimmune hypothyroidism.
PATIENT REPORT: The infant was transferred to the Pediatric Clinic, University of Catania, Italy for evaluation of dysmorphic features, growth and motor retardation, and hypothyroidism on laboratory testing. Neonatal screening test for TSH and PKU was negative. An ultrasound scan showed a non-homogeneous thyroid gland which was increased in volume. Based on the laboratory results, the diagnosis of autoimmune hypothyroidism was made and L-thyroxine treatment was initiated at 50 microg/day.
CONCLUSIONS: Autoimmune hypothyroidism in infancy is rare, but early recognition and therapy are essential to prevent neurologic damage and growth deficits. In this patient we would like to underline the early age of appearance of autoimmune thyroid disease and the possible onset of pathologic events before birth.
Authors:
Lorenzo Pavone; Giovanna Vitaliti; Manuela Caruso; Piero Pavone
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  23     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-12-22     Completed Date:  2011-01-13     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  957-61     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, University of Catania, Italy. lorenzo_pavone@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Autoimmune Diseases / diagnosis*,  etiology
Diagnosis, Differential
Female
Humans
Hypothyroidism / diagnosis*,  etiology
Infant

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