Document Detail

Neonatal assessment of babies conceived by in vitro fertilization.
MedLine Citation:
PMID:  9447536     Owner:  NLM     Status:  MEDLINE    
PROBLEM: Neonatal outcome of in vitro fertilization (IVF) pregnancies has been described by different authors, but several issues have yet to be resolved. The aim of the present study was to evaluate neonates conceived in vitro and to direct special attention to neonatal morbidity and prevalence of minor abnormalities. The information that has been accumulated so far is scant. METHOD: The first 100 babies conceived in vitro, and subsequently born in our institute, were investigated and compared with the general, spontaneously conceived newborn population. All infants were examined by a senior neonatologist, and the data that were recorded included gestational age at delivery, birth weight, gender, major malformations, minor congenital abnormalities, neonatal mortality, and neonatal morbidity (including asphyxia, jaundice, meconium aspiration, hypoglycemia, and hypocalcemia). RESULTS AND CONCLUSIONS: The data indicate that the IVF neonates assessed had a higher rate of low birth weight (37%), twinning (30%), and preterm birth (20%) in comparison with the general reference population (p < 0.05). However, no differences were encountered either in the rate of small for gestational age infants or the incidence of major malformations and minor abnormalities between these groups of newborns. The overall neonatal morbidity in IVF babies was found to exceed that of the general population. Nevertheless, at birth, there were no clinical pathognomonic signs typical of IVF babies, although more detailed metabolic, endocrine, and neurobehavioral studies are still required to confirm that newborns conceived in vitro do not differ from those conceived spontaneously in any of these respects.
B Fisch; L Harel; B Kaplan; H Pinkas; S Amit; J Ovadia; Y Tadir; P Merlob
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  17     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:    1997 Nov-Dec
Date Detail:
Created Date:  1998-03-04     Completed Date:  1998-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  473-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Rabin Medical Center-Beilinson Campus, Petah Tiqwa, Israel.
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MeSH Terms
Fertilization in Vitro*
Gestational Age
Infant Mortality
Infant, Newborn
Infant, Newborn, Diseases / epidemiology,  etiology
Infant, Premature
Obstetric Labor, Premature
Pregnancy Outcome / epidemiology*
Pregnancy, Multiple
Risk Factors

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