| Neonatal antecedents for cerebral palsy in extremely preterm babies and interaction with maternal factors. | |
| | |
MedLine Citation:
|
PMID: 15935933 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Preterm delivery is associated with an increased risk of cerebral palsy (CP). The greatest risk is for infants born <28 weeks' gestation. AIMS: To identify significant neonatal risk factors for CP and explore the interactions between antenatal and neonatal risk factors, among extremely preterm infants of 27 weeks' gestation or less. STUDY DESIGN: Nested case control design. METHODS: Infants born between 1989 and 1996, at 24-27 weeks' gestation, were evaluated: 30 with CP at 2 years corrected age and 120 control infants matched for gestation age. Neonatal variables were compared using matched analyses with the interaction between antenatal and neonatal factors being examined using logistic regression analyses. RESULTS: Risk factors for CP on matched analyses included patent ductus arteriosus requiring surgical ligation, peri-intraventricular haemorrhage, moderate to severe ventricular dilatation, periventricular leukomalacia (PVL) and need for home oxygen. Independent neonatal predictors were ventricular dilatation (OR 7.3; 95% CI 1.6, 32.3), PVL (OR 29.8; 95% CI 5.6, 159.1) and home oxygen use (OR 3.4; 95% CI 1.2, 9.4). No interaction terms in the logistic models were significant between the previously identified pregnancy risk factors of absence of antenatal steroids and intrauterine growth restriction and the neonatal risk factors. CONCLUSIONS: PVL is the most powerful independent predictor of CP in extremely preterm infants of 27 weeks' gestation or less and appears to be uninfluenced by antenatal factors. |
| | |
Authors:
|
Uyen Tran; Peter H Gray; Michael J O'Callaghan |
Related Documents
:
|
18591303 - Delivery mode and severe intraventricular hemorrhage in single, very low birth weight, ... 22841183 - Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion. 2925943 - Genetic effects on dairy calf growth. |
Publication Detail:
|
Type: Journal Article Date: 2005-02-24 |
Journal Detail:
|
Title: Early human development Volume: 81 ISSN: 0378-3782 ISO Abbreviation: Early Hum. Dev. Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-06-06 Completed Date: 2006-01-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: Ireland |
Other Details:
|
Languages: eng Pagination: 555-61 Citation Subset: IM |
Affiliation:
|
Developmental Paediatrics and Rehabilitation, University of Queensland, Mater Children's Hospital, South Brisbane, Queensland, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cerebral Palsy
/
diagnosis*,
etiology* Female Humans Infant Infant, Newborn Infant, Premature Leukomalacia, Periventricular / complications* Logistic Models Male Pregnancy Premature Birth / complications* Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Risk factors for cerebral palsy in preterm infants.
Next Document: Problematic behaviours of 3-year-old children in Japan: relationship with socioeconomic and family b...