| Neonatal alloimmune thrombocytopenia. | |
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MedLine Citation:
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PMID: 2676035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neonatal alloimmune thrombocytopenia (NAIT) occurs when maternal alloantibodies to antigens present on fetal platelets cause their immune destruction resulting in thrombocytopenia in the newborn infant or fetus. Bleeding may be severe; intracranial haemorrhage and permanent neurological damage are the most serious complications. Despite the severity of the disease, there is often a delay in making the correct diagnosis and instigating appropriate treatment. Recent evidence that NAIT is more common than has previously been recognised, a better understanding of the molecular basis of platelet serology and advances in technology, which have made it possible to take blood samples from fetuses and transfuse them in utero, have all contributed to a growing interest in this condition. In addition, it is exciting to realise that an aggressive approach to the management of established cases and 'at risk' pregnancies can prevent serious neurological sequelae and dramatically improve the outcome for affected infants. |
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Authors:
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P O Skacel; M Contreras |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Blood reviews Volume: 3 ISSN: 0268-960X ISO Abbreviation: Blood Rev. Publication Date: 1989 Sep |
Date Detail:
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Created Date: 1989-11-02 Completed Date: 1989-11-02 Revised Date: 2006-08-26 |
Medline Journal Info:
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Nlm Unique ID: 8708558 Medline TA: Blood Rev Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 174-9 Citation Subset: IM |
Affiliation:
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Department of Haematology, Northwick Park Hospital, Harrow, Middlesex, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Human Platelet* Blood Platelets / immunology* Female Fetal Diseases* Humans Infant, Newborn Isoantibodies* Isoantigens / immunology* Pregnancy Thrombocytopenia* |
| Chemical | |
Reg. No./Substance:
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0/1a alloantigen, human; 0/Antigens, Human Platelet; 0/Isoantibodies; 0/Isoantigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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