Document Detail


Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management.
MedLine Citation:
PMID:  23384054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal alloimmune thrombocytopenia, (NAIT) is caused by maternal antibodies raised against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a significant cause of morbidity and mortality in newborns and is the most common cause of intracranial haemorrhage in full-term infants. In this report, we review the pathogenesis, clinical presentation, laboratory diagnosis and prenatal and post-natal management of NAIT and highlight areas of controversy that deserve the attention of clinical and laboratory investigators.
Authors:
Julie A Peterson; Janice G McFarland; Brian R Curtis; Richard H Aster
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-02-06
Journal Detail:
Title:  British journal of haematology     Volume:  161     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-05-21     Revised Date:  2014-04-10    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  3-14     Citation Subset:  IM    
Copyright Information:
© 2013 Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Antigens, Human Platelet / immunology
Biological Markers / blood
Female
Humans
Infant, Newborn
Perinatal Care / methods
Platelet Transfusion / methods
Pregnancy
Prenatal Care / methods
Thrombocytopenia, Neonatal Alloimmune / diagnosis*,  immunology,  therapy
Grant Support
ID/Acronym/Agency:
R01 HL013629/HL/NHLBI NIH HHS; R21 HL079085/HL/NHLBI NIH HHS; R56 HL013629/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, Human Platelet; 0/Biological Markers
Comments/Corrections

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