| Neonatal acid base balance and disturbances. | |
| | |
MedLine Citation:
|
PMID: 15200248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Maintaining acid base balance presents a considerable challenge to the growing neonate. The infant must ingest protein for growth and development. The metabolism of sulfur containing amino acids leads to the production of protons that must be secreted by the kidney. In addition, the formation of hydroxyapatite for the mineralization of growing bone also leads to acid production. Thus, the growing infant must excrete approximately 2 to 3 mEq of acid per kilogram of body weight per day to avoid becoming acidotic. The mechanisms for excreting acid undergo complex maturational changes that predispose the neonate, and the premature neonate in particular, to a great risk for the development of acidosis. In addition, infants are susceptible to gastrointestinal disturbances that can lead to acidosis due to acute loss of bicarbonate in the stool. The kidney is then responsible for the production of new bicarbonate to restore the body's acid base balance. There are also a number of inherited disorders in the kidney that affect acid secretion and lead to acid base disturbances in neonates. This review discusses the mechanisms by which the kidney is capable of excreting acid as well as the developmental regulation of these processes and the basis of inherited disorders of acidification. |
| | |
Authors:
|
Raymond Quigley; Michel Baum |
Related Documents
:
|
8694698 - Effect of an pyruvate-based peritoneal dialysis solution on the ph of a residual perito... 8141148 - Acid-base abnormalities in hypertension. 9234228 - Evaluation of blood acid-base balance after experimental administration of endotoxin in... 10902188 - Identifying amino acid residues in medium resolution critical point graphs using instan... 3226918 - Synthesis and application of a new phosphorylating agent: s-(n-monomethoxytritylaminoet... 1464048 - In vitro evaluation of acaricidal and fungicidal activity of the house dust mite acaric... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Seminars in perinatology Volume: 28 ISSN: 0146-0005 ISO Abbreviation: Semin. Perinatol. Publication Date: 2004 Apr |
Date Detail:
|
Created Date: 2004-06-17 Completed Date: 2004-07-06 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
|
Languages: eng Pagination: 97-102 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9063, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acid-Base Equilibrium
/
physiology* Acid-Base Imbalance* / etiology, genetics, physiopathology Humans Infant, Newborn |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ontogeny of renal sodium transport.
Next Document: Renal potassium handling in healthy and sick newborns.