Document Detail

Neonatal abstinence syndrome after in utero exposure to selective serotonin reuptake inhibitors in term infants.
MedLine Citation:
PMID:  16461873     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the prevalence and clinical characteristics of neonatal abstinence syndrome in neonates exposed and not exposed to selective serotonin reuptake inhibitors (SSRIs) in utero. DESIGN: Cohort study. SETTING: Tertiary care center. Patients One hundred twenty term infants, of whom 60 had prolonged in utero exposure to SSRIs, including paroxetine hydrochloride, fluoxetine, citalopram hydrobromide, sertraline hydrochloride, and venlafaxine hydrochloride. MAIN OUTCOME MEASURES: Neonatal abstinence syndrome was assessed with the Finnegan score as follows: score of 8 or above, severe; score of 4 to 7, mild; and score of 0 to 3, normal. All infants were followed up with a standardized protocol that included repeated Finnegan score assessments and cardiorespiratory monitoring until normalization of the Finnegan score. RESULTS: Of the 60 neonates exposed to SSRIs in utero, 8 showed severe and 10 showed mild symptoms of a neonatal abstinence syndrome. All nonexposed neonates had a normal Finnegan score. In neonates who developed severe symptoms, the maximum mean daily Finnegan scores were recorded within 2 days after birth, although maximum individual scores were recorded as long as 4 days after birth. CONCLUSIONS: Neonatal abstinence syndrome occurs in 30% of neonates exposed to SSRIs in utero. These neonates should be monitored for at least 48 hours after birth. The long-term effects of prolonged exposure to SSRIs, particularly in neonates who develop severe symptoms, have yet to be determined.
Rachel Levinson-Castiel; Paul Merlob; Nehama Linder; Lea Sirota; Gil Klinger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of pediatrics & adolescent medicine     Volume:  160     ISSN:  1072-4710     ISO Abbreviation:  Arch Pediatr Adolesc Med     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-03-21     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9422751     Medline TA:  Arch Pediatr Adolesc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  173-6     Citation Subset:  AIM; IM    
Neonatal Intensive Care Unit, Schneider Children's Medical Center of Israel, 14 Kaplan Street, Petah Tiqwa, Israel 49202.
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MeSH Terms
Cohort Studies
Infant, Newborn
Maternal-Fetal Exchange*
Neonatal Abstinence Syndrome / epidemiology*,  etiology*
Serotonin Uptake Inhibitors / adverse effects*
Reg. No./Substance:
0/Serotonin Uptake Inhibitors
Comment In:
Arch Pediatr Adolesc Med. 2006 Aug;160(8):855-6; author reply 856   [PMID:  16894088 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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