Document Detail

Neonatal Torulopsis glabrata fungemia.
MedLine Citation:
PMID:  9042184     Owner:  NLM     Status:  MEDLINE    
Torulopsis glabrata is a yeastlike fungus that has recently become recognized as an important opportunistic pathogen. Only four cases of T glabrata infection in neonates have been reported. We report two cases of fungemia caused by this organism in premature infants. Both patients were treated with amphotericin B and survived the fungemia, but one patient later died of bacterial sepsis. Both patients had been treated with surfactant, artificial ventilation, intravascular catheters (arterial and venous), broad spectrum antibiotics, and hyperalimentation, which appear to be risk factors for T glabrata fungemia. A review of the literature indicates that T glabrata is susceptible to amphotericin B and 5-fluorocytosine and is resistant to fluconazole. In addition, it is less susceptible to ketoconazole, clotrimazole, and itraconazole than is Candida albicans. We recommend that T glabrata infections be treated initially by reducing iatrogenic risk factors and beginning amphotericin B therapy. If necessary, 5-fluorocytosine should be added to the drug regimen.
J D Reich; K Huddleston; D Jorgensen; F E Berkowitz
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Southern medical journal     Volume:  90     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-03-19     Completed Date:  1997-03-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  246-8     Citation Subset:  AIM; IM    
Department of Pediatrics, Emory University School of Medicine, Atlanta, Ga. 30303, USA.
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MeSH Terms
Amphotericin B / therapeutic use
Antifungal Agents / therapeutic use
Candida / isolation & purification*
Candidiasis / drug therapy*
Fatal Outcome
Infant, Newborn
Infant, Premature*
Respiration, Artificial
Reg. No./Substance:
0/Antifungal Agents; 1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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