| Neonatal Torulopsis glabrata fungemia. | |
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MedLine Citation:
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PMID: 9042184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Torulopsis glabrata is a yeastlike fungus that has recently become recognized as an important opportunistic pathogen. Only four cases of T glabrata infection in neonates have been reported. We report two cases of fungemia caused by this organism in premature infants. Both patients were treated with amphotericin B and survived the fungemia, but one patient later died of bacterial sepsis. Both patients had been treated with surfactant, artificial ventilation, intravascular catheters (arterial and venous), broad spectrum antibiotics, and hyperalimentation, which appear to be risk factors for T glabrata fungemia. A review of the literature indicates that T glabrata is susceptible to amphotericin B and 5-fluorocytosine and is resistant to fluconazole. In addition, it is less susceptible to ketoconazole, clotrimazole, and itraconazole than is Candida albicans. We recommend that T glabrata infections be treated initially by reducing iatrogenic risk factors and beginning amphotericin B therapy. If necessary, 5-fluorocytosine should be added to the drug regimen. |
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Authors:
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J D Reich; K Huddleston; D Jorgensen; F E Berkowitz |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Southern medical journal Volume: 90 ISSN: 0038-4348 ISO Abbreviation: South. Med. J. Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-03-19 Completed Date: 1997-03-19 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 246-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Emory University School of Medicine, Atlanta, Ga. 30303, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amphotericin B
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therapeutic use Antifungal Agents / therapeutic use Candida / isolation & purification* Candidiasis / drug therapy* Fatal Outcome Female Humans Infant, Newborn Infant, Premature* Respiration, Artificial |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 1397-89-3/Amphotericin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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