Document Detail

Neonatal thyroid function: effect of a single exposure to iodinated contrast medium in utero.
MedLine Citation:
PMID:  20634430     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the effect of in utero exposure to a single dose of water-soluble intravenous iodinated contrast medium on thyroid function at birth. MATERIALS AND METHODS: This study was approved by the institutional review board, with waiver of consent, and was HIPAA compliant. Maternal and newborn records were retrospectively reviewed. All pregnant women who underwent multidetector pulmonary computed tomographic angiography because they were suspected of having pulmonary embolism between 2004 and 2008 and newborns resulting from the index pregnancy were included. In all examinations, iohexol was used as the contrast agent. Dose and amount of contrast agent and gestational age at the time of administration of the contrast agent were collected, and thyroxine (T(4)) and thyroid-stimulating hormone (TSH) levels were measured at birth. A total of 344 maternal and 343 newborn records were reviewed. A descriptive analysis was performed, and means, standard deviations, and confidence intervals were reported. RESULTS: Mean gestational age at the time of administration of the contrast material was 27.8 weeks +/- 7.4. The mean dose of total iodine administered was 45,000 mg/L +/- 7321. All newborns had a normal T(4) level at birth; only one newborn had a transiently abnormal TSH level at birth, which normalized at day 6 of life. This newborn was born to a mother who had many drug exposures during pregnancy. CONCLUSION: A single, high-dose in utero exposure to water-soluble, low-osmolar, iodinated intravenous products, such as iohexol, is unlikely to have a clinically important effect on thyroid function at birth.
Ghada Bourjeily; Michel Chalhoub; Chanika Phornphutkul; Thelma C Alleyne; Courtney A Woodfield; Kenneth K Chen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-15
Journal Detail:
Title:  Radiology     Volume:  256     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-19     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  744-50     Citation Subset:  AIM; IM    
Copyright Information:
(c) RSNA, 2010.
Department of Medicine, Pulmonary and Critical Care Medicine, Women and Infants Hospital of Rhode Island, Providence, RI, USA.
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MeSH Terms
Contrast Media / administration & dosage,  adverse effects*
Dose-Response Relationship, Drug
Infant, Newborn
Iohexol / administration & dosage,  adverse effects*
Pregnancy Outcome
Prenatal Exposure Delayed Effects / chemically induced*
Pulmonary Embolism / radiography
Retrospective Studies
Thyroid Function Tests
Thyroid Gland / drug effects*,  embryology
Thyrotropin / blood
Tomography, X-Ray Computed
Reg. No./Substance:
0/Contrast Media; 66108-95-0/Iohexol; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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